Talazoparib Does Not Interact with ABCB1 Transporter or Cytochrome P450s, but Modulates Multidrug Resistance Mediated by ABCC1 and ABCG2: An in Vitro and Ex Vivo Study.

Sabet, Ziba; Vagiannis, Dimitrios; Budagaga, Youssif; Zhang, Yu; Novotná, Eva; Hanke, Ivo; Rozkos, Tomás; Hofman, Jakub

Sabet, Ziba; Vagiannis, Dimitrios; Budagaga, Youssif; Zhang, Yu; Novotná, Eva; Hanke, Ivo; Rozkos, Tomás; Hofman, Jakub.

Afiliação

Sabet Z; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovskeho 1203, 500 05 Hradec Králové, Czech Republic.
Vagiannis D; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovskeho 1203, 500 05 Hradec Králové, Czech Republic.
Budagaga Y; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovskeho 1203, 500 05 Hradec Králové, Czech Republic.
Zhang Y; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovskeho 1203, 500 05 Hradec Králové, Czech Republic.
Novotná E; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovskeho 1203, 500 05 Hradec Králové, Czech Republic.
Hanke I; Department of Cardiac Surgery, Faculty of Medicine, Charles University in Hradec Králové and University Hospital Hradec Králové, Sokolská 581, 500 05 Hradec Králové, Czech Republic.
Rozkos T; The Fingerland Department of Pathology, Charles University, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic, Sokolská 581, 500 05 Hradec Králové, Czech Republic.
Hofman J; Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Heyrovskeho 1203, 500 05 Hradec Králové, Czech Republic.

Int J Mol Sci ; 23(22)2022 Nov 18.

Article em En | MEDLINE | ID: mdl-36430819

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Humanos; Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico; Carcinoma Pulmonar de Células não Pequenas/genética; Resistência a Múltiplos Medicamentos; Transportadores de Cassetes de Ligação de ATP/genética; Transportadores de Cassetes de Ligação de ATP/metabolismo; Sistema Enzimático do Citocromo P-450/metabolismo; Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP/genética; Proteínas de Neoplasias/metabolismo; Subfamília B de Transportador de Cassetes de Ligação de ATP/genética

Palavras-chave

ABC transporter; cytochrome P450; multidrug resistance; pharmacokinetic drugdrug interaction; small cell lung cancer; talazoparib

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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