Inhibition of NF-kB/IL-6/JAK2/STAT3 Pathway and Epithelial-Mesenchymal Transition in Breast Cancer Cells by Azilsartan.

Alaaeldin, Rania; Ali, Fares E M; Bekhit, Amany Abdlrehim; Zhao, Qing-Li; Fathy, Moustafa

Alaaeldin, Rania; Ali, Fares E M; Bekhit, Amany Abdlrehim; Zhao, Qing-Li; Fathy, Moustafa.

Afiliação

Alaaeldin R; Department of Biochemistry, Faculty of Pharmacy, Deraya University, Minia 61111, Egypt.
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.
Bekhit AA; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Zhao QL; Department of Radiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Japan.
Fathy M; Department of Biochemistry, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.

Molecules ; 27(22)2022 Nov 13.

Article em En | MEDLINE | ID: mdl-36431925

Assuntos

Neoplasias da Mama; Transição Epitelial-Mesenquimal; Humanos; Feminino; NF-kappa B/metabolismo; Interleucina-6/metabolismo; Metaloproteinase 9 da Matriz/metabolismo; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Proteína X Associada a bcl-2/metabolismo; Linhagem Celular Tumoral; RNA Mensageiro; Janus Quinase 2/metabolismo; Fator de Transcrição STAT3/genética; Fator de Transcrição STAT3/metabolismo

Palavras-chave

EMT; IL-6/JAK2/STAT3; NF-kB; SLUG; SNAIL; TWIST; azilsartan; breast cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Transição Epitelial-Mesenquimal Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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