Oncolytic virus-mediated reducing of myeloid-derived suppressor cells enhances the efficacy of PD-L1 blockade in gemcitabine-resistant pancreatic cancer.

Kajiwara, Yoshinori; Tazawa, Hiroshi; Yamada, Motohiko; Kanaya, Nobuhiko; Fushimi, Takuro; Kikuchi, Satoru; Kuroda, Shinji; Ohara, Toshiaki; Noma, Kazuhiro; Yoshida, Ryuichi; Umeda, Yuzo; Urata, Yasuo; Kagawa, Shunsuke; Fujiwara, Toshiyoshi

Kajiwara, Yoshinori; Tazawa, Hiroshi; Yamada, Motohiko; Kanaya, Nobuhiko; Fushimi, Takuro; Kikuchi, Satoru; Kuroda, Shinji; Ohara, Toshiaki; Noma, Kazuhiro; Yoshida, Ryuichi; Umeda, Yuzo; Urata, Yasuo; Kagawa, Shunsuke; Fujiwara, Toshiyoshi.

Afiliação

Kajiwara Y; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Tazawa H; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan. htazawa@md.okayama-u.ac.jp.
Yamada M; Center for Innovative Clinical Medicine, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan. htazawa@md.okayama-u.ac.jp.
Kanaya N; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Fushimi T; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Kikuchi S; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Kuroda S; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Ohara T; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Noma K; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Yoshida R; Department of Pathology and Experimental Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Umeda Y; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Urata Y; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Kagawa S; Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, 700-8558, Japan.
Fujiwara T; Oncolys BioPharma Inc., Tokyo, 105-0001, Japan.

Cancer Immunol Immunother ; 72(5): 1285-1300, 2023 May.

Article em En | MEDLINE | ID: mdl-36436021

Assuntos

Carcinoma Ductal Pancreático; Células Supressoras Mieloides; Vírus Oncolíticos; Neoplasias Pancreáticas; Camundongos; Animais; Humanos; Gencitabina; Células Supressoras Mieloides/metabolismo; Fator Estimulador de Colônias de Granulócitos e Macrófagos/farmacologia; Antígeno B7-H1/metabolismo; Carcinoma Ductal Pancreático/metabolismo; Imunossupressores/uso terapêutico; Microambiente Tumoral; Linhagem Celular Tumoral; Neoplasias Pancreáticas

Palavras-chave

Chemoresistance; GM-CSF; MDSC; Oncolytic virus; Pancreatic cancer

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Vírus Oncolíticos / Células Supressoras Mieloides Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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