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Characterization of a new potent and long-lasting single chain peptide agonist of RXFP1 in cells and in vivo translational models.
Illiano, Stephane; Poirier, Bruno; Minoletti, Claire; Pasquier, Olivier; Riva, Laurence; Chenede, Xavier; Menguy, Isabelle; Guillotel, Michel; Prigent, Philippe; Le Claire, Stéphane; Gillot, Florence; Thill, Gilbert; Lo Presti, François; Corbier, Alain; Le Bail, Jean-Christophe; Grailhe, Patrick; Monteagudo, Edith; Ingenito, Raffaele; Bianchi, Elisabetta; Philippo, Christophe; Duclos, Olivier; Mallart, Sergio; Bathgate, Ross; Janiak, Philip.
Afiliação
  • Illiano S; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France. stephane.illiano@irsn.fr.
  • Poirier B; IRSN, B.P. 17, 92262, Fontenay-Aux-Roses Cedex, France. stephane.illiano@irsn.fr.
  • Minoletti C; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Pasquier O; Integrated Drug Discovery, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Riva L; DMPK France, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Chenede X; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Menguy I; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Guillotel M; Integrated Drug Discovery, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Prigent P; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Le Claire S; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Gillot F; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Thill G; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Lo Presti F; Translational Science, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Corbier A; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Le Bail JC; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Grailhe P; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Monteagudo E; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Ingenito R; Peptides and Small Molecules R&D Department, ≠DMPK, and Structural Biology IRBM Spa, Via Pontina Km 30 600, 00 071, Pomezia, RM, Italy.
  • Bianchi E; Peptides and Small Molecules R&D Department, ≠DMPK, and Structural Biology IRBM Spa, Via Pontina Km 30 600, 00 071, Pomezia, RM, Italy.
  • Philippo C; Peptides and Small Molecules R&D Department, ≠DMPK, and Structural Biology IRBM Spa, Via Pontina Km 30 600, 00 071, Pomezia, RM, Italy.
  • Duclos O; Cardio-Vascular and Metabolism, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Mallart S; Integrated Drug Discovery, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Bathgate R; Integrated Drug Discovery, Sanofi R&D, 1 avenue Pierre Brossolette, 91385, Chilly-Mazarin, France.
  • Janiak P; Structural biology and chemistry, Institut Pasteur, PARIS, France.
Sci Rep ; 12(1): 20435, 2022 11 28.
Article em En | MEDLINE | ID: mdl-36443381
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relaxina Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relaxina Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article