Pharmacological and Pathological Relevance of S100 Proteins in Neurological Disorders.
CNS Neurol Disord Drug Targets
; 22(10): 1403-1416, 2023.
Article
em En
| MEDLINE
| ID: mdl-36443979
ABSTRACT
The S100 protein is one of the calcium-binding proteins associated with Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. S100 proteins are expressed in the central nervous system by oligodendrocytes, astrocytes and neurons during both normal and disease conditions. Although amyloid-beta aggregation and hyperphosphorylated tau plaques are the main pathological hallmarks of Alzheimer's disease, the S100 protein family is closely associated with neuroinflammation in several neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis in addition to various types of cancer and other brain diseases. This review aims to present the key role of S100 proteins and their different relevant isoforms, along with the various approaches used for the regulation of these proteins in several neurodegenerative disorders.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
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Doença de Alzheimer
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Esclerose Lateral Amiotrófica
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Doenças do Sistema Nervoso
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article