Synthesis and biological evaluation of novel photo-clickable adenosine and cyclic ADP-ribose analogs: 8-N<sub>3</sub>-2'-O-propargyladenosine and 8-N<sub>3</sub>-2'-O-propargyl-cADPR.

Andy, Divya; Gunaratne, Gihan S; Marchant, Jonathan S; Walseth, Timothy F; Slama, James T

Synthesis and biological evaluation of novel photo-clickable adenosine and cyclic ADP-ribose analogs: 8-N₃-2'-O-propargyladenosine and 8-N₃-2'-O-propargyl-cADPR.

Andy, Divya; Gunaratne, Gihan S; Marchant, Jonathan S; Walseth, Timothy F; Slama, James T.

Afiliação

Andy D; Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614, USA.
Gunaratne GS; Department of Pharmacology, University of Minnesota Medical School, 312 Church St, Minneapolis, MN 55455-0217, USA.
Marchant JS; Department of Cell Biology, Neurobiology & Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, USA.
Walseth TF; Department of Pharmacology, University of Minnesota Medical School, 312 Church St, Minneapolis, MN 55455-0217, USA.
Slama JT; Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614, USA. Electronic address: james.slama@utoledo.edu.

Bioorg Med Chem ; 76: 117099, 2022 12 15.

Article em En | MEDLINE | ID: mdl-36446271

Assuntos

ADP-Ribose Cíclica; NAD; Humanos; ADP-Ribose Cíclica/farmacologia; Adenosina/farmacologia

Palavras-chave

Activity based probe; Ca(2+) signaling; Click chemistry; Cyclic ADP-ribose; NAD(+); Nucleoside; Nucleotide; Photoaffinity label

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: ADP-Ribose Cíclica / NAD Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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