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A stable, engineered TL1A ligand co-stimulates T cells via specific binding to DR3.
Zwolak, Adam; Chan, Szeman Ruby; Harvilla, Paul; Mahady, Sally; Armstrong, Anthony A; Luistro, Leopoldo; Tamot, Ninkka; Yamada, Douglas; Derebe, Mehabaw; Pomerantz, Steven; Chiu, Mark; Ganesan, Rajkumar; Chowdhury, Partha.
Afiliação
  • Zwolak A; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA. azwolak1@its.jnj.com.
  • Chan SR; Oncology Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Harvilla P; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Mahady S; Oncology Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Armstrong AA; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Luistro L; Oncology Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Tamot N; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Yamada D; Oncology Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Derebe M; Merck Research Laboratories, Discovery Biologics, Protein Sciences, South San Francisco, CA, USA.
  • Pomerantz S; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Chiu M; Tavotek Biotherapeutics, Spring House, PA, USA.
  • Ganesan R; Immunotherapeutics, Amgen, South San Francisco, CA, USA.
  • Chowdhury P; Cell Engineering and Early Development, Janssen Research & Development, Spring House, PA, USA.
Sci Rep ; 12(1): 20538, 2022 11 29.
Article em En | MEDLINE | ID: mdl-36446890
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Membro 15 da Superfamília de Ligantes de Fatores de Necrose Tumoral Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Membro 15 da Superfamília de Ligantes de Fatores de Necrose Tumoral Idioma: En Ano de publicação: 2022 Tipo de documento: Article