Your browser doesn't support javascript.
loading
Club Cell Secretory Protein in Lung Disease: Emerging Concepts and Potential Therapeutics.
Martinu, Tereza; Todd, Jamie L; Gelman, Andrew E; Guerra, Stefano; Palmer, Scott M.
Afiliação
  • Martinu T; Department of Medicine, University of Toronto, Toronto, Ontario, Canada; email: tereza.martinu@uhn.ca.
  • Todd JL; Division of Respirology, Department of Medicine, University Health Network, Toronto, Ontario, Canada.
  • Gelman AE; Toronto Lung Transplant Program, Ajmera Transplant Centre, University Health Network, Toronto, Ontario, Canada.
  • Guerra S; Division of Pulmonary, Allergy and Critical Care, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
  • Palmer SM; Duke Clinical Research Institute, Durham, North Carolina, USA.
Annu Rev Med ; 74: 427-441, 2023 01 27.
Article em En | MEDLINE | ID: mdl-36450281
Club cell secretory protein (CCSP), also known as secretoglobin 1A1 (gene name SCGB1A1), is one of the most abundant proteins in the lung, primarily produced by club cells of the distal airway epithelium. At baseline, CCSP is found in large concentrations in lung fluid specimens and can also be detected in the blood and urine. Obstructive lung diseases are generally associated with reduced CCSP levels, thought to be due to decreased CCSP production or club cell depletion. Conversely, several restrictive lung diseases have been found to have increased CCSP levels both in the lung and in the circulation, likely related to club cell dysregulation as well as increasedlung permeability. Recent studies demonstrate multiple mechanisms by which CCSP dampens acute and chronic lung inflammation. Given these anti-inflammatory effects, CCSP represents a novel potential therapeutic modality in lung disease.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumopatias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pneumopatias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article