Differential involvement of LUBAC-mediated linear ubiquitination in intestinal epithelial cells and macrophages during intestinal inflammation.

Sakamoto, Yusuke; Sasaki, Katsuhiro; Omatsu, Mayuki; Hamada, Kensuke; Nakanishi, Yuki; Itatani, Yoshiro; Kawada, Kenji; Obama, Kazutaka; Seno, Hiroshi; Iwai, Kazuhiro

Sakamoto, Yusuke; Sasaki, Katsuhiro; Omatsu, Mayuki; Hamada, Kensuke; Nakanishi, Yuki; Itatani, Yoshiro; Kawada, Kenji; Obama, Kazutaka; Seno, Hiroshi; Iwai, Kazuhiro.

Afiliação

Sakamoto Y; Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sasaki K; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Omatsu M; Department of Molecular and Cellular Physiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hamada K; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Nakanishi Y; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Itatani Y; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kawada K; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Obama K; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Seno H; Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Iwai K; Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

J Pathol ; 259(3): 304-317, 2023 03.

Article em En | MEDLINE | ID: mdl-36454102

Assuntos

Colite; NF-kappa B; Camundongos; Animais; NF-kappa B/metabolismo; Inibidores do Fator de Necrose Tumoral/efeitos adversos; Inibidores do Fator de Necrose Tumoral/metabolismo; Colite/patologia; Células Epiteliais/patologia; Macrófagos/patologia; Ubiquitinação; Inflamação/patologia; Ligases/metabolismo; Sulfato de Dextrana/efeitos adversos; Sulfato de Dextrana/metabolismo

Palavras-chave

DSS; IBD; LPS; LUBAC; NF-κB; cell death; intestinal epithelial cells; intestinal inflammation; linear ubiquitination; macrophages

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: NF-kappa B / Colite Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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