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Bivariate GWAS reveals pleiotropic regions among feed efficiency and beef quality-related traits in Nelore cattle.
Buss, Carlos Eduardo; Afonso, Juliana; de Oliveira, Priscila S N; Petrini, Juliana; Tizioto, Polyana Cristine; Cesar, Aline S M; Gustani-Buss, Emanuele Cristina; Cardoso, Tainã Figueiredo; Rovadoski, Gregori A; da Silva Diniz, Wellison Jarles; de Lima, Andressa Oliveira; Rocha, Marina Ibelli Pereira; Andrade, Bruno Gabriel Nascimento; Wolf, Jason B; Coutinho, Luiz Lehmann; Mourão, Gerson Barreto; de Almeida Regitano, Luciana Correia.
Afiliação
  • Buss CE; Department of Genetic and Evolution, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • Afonso J; Mindflow Genomics, Leuven, Flanders, Belgium.
  • de Oliveira PSN; Embrapa Southeast Cattle, Fazenda Canchim, Rodovia Washington Luiz, Km 234, S/N, São Carlos, São Paulo, Brazil.
  • Petrini J; Department of Genetic and Evolution, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • Tizioto PC; Department of Animal Science, University of São Paulo/ESALQ, Piracicaba, São Paulo, Brazil.
  • Cesar ASM; NGS Soluções Genômicas, Piracicaba, São Paulo, Brazil.
  • Gustani-Buss EC; Department of Agroindustry, Food and Nutrition, University of São Paulo/ESALQ, Piracicaba, São Paulo, Brazil.
  • Cardoso TF; Mindflow Genomics, Leuven, Flanders, Belgium.
  • Rovadoski GA; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000, Leuven, Belgium.
  • da Silva Diniz WJ; Embrapa Southeast Cattle, Fazenda Canchim, Rodovia Washington Luiz, Km 234, S/N, São Carlos, São Paulo, Brazil.
  • de Lima AO; Department of Animal Science, University of São Paulo/ESALQ, Piracicaba, São Paulo, Brazil.
  • Rocha MIP; Department of Animal Sciences, Auburn University, Auburn, AL, USA.
  • Andrade BGN; Division of Medical Genetics, Department of Genomics Science, University of Washington, Seattle, WA, USA.
  • Wolf JB; Department of Genetic and Evolution, Federal University of São Carlos, São Carlos, São Paulo, Brazil.
  • Coutinho LL; Embrapa Southeast Cattle, Fazenda Canchim, Rodovia Washington Luiz, Km 234, S/N, São Carlos, São Paulo, Brazil.
  • Mourão GB; Department of Computer Science, Munster Technological University/MTU, Cork, Ireland.
  • de Almeida Regitano LC; Department of Biology & Biochemistry, Milner Centre for Evolution Bath, University of Bath, Bath, BA2 7AY, UK.
Mamm Genome ; 34(1): 90-103, 2023 03.
Article em En | MEDLINE | ID: mdl-36463529
ABSTRACT
Feed-efficient cattle selection is among the most leading solutions to reduce cost for beef cattle production. However, technical difficulties in measuring feed efficiency traits had limited the application in livestock. Here, we performed a Bivariate Genome-Wide Association Study (Bi-GWAS) and presented candidate biological mechanisms underlying the association between feed efficiency and meat quality traits in a half-sibling design with 353 Nelore steers derived from 34 unrelated sires. A total of 13 Quantitative Trait Loci (QTL) were found explaining part of the phenotypic variations. An important transcription factor of adipogenesis in cattle, the TAL1 (rs133408775) gene located on BTA3 was associated with intramuscular fat and average daily gain (IMF-ADG), and a region located on BTA20, close to CD180 and MAST4 genes, both related to fat accumulation. We observed a low positive genetic correlation between IMF-ADG (r = 0.30 ± 0.0686), indicating that it may respond to selection in the same direction. Our findings contributed to clarifying the pleiotropic modulation of the complex traits, indicating new QTLs for bovine genetic improvement.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Locos de Características Quantitativas / Estudo de Associação Genômica Ampla Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Locos de Características Quantitativas / Estudo de Associação Genômica Ampla Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article