A structural mechanism of nuclear receptor biased agonism.

Nemetchek, Michelle D; Chrisman, Ian M; Rayl, Mariah L; Voss, Andrew H; Hughes, Travis S

Nemetchek, Michelle D; Chrisman, Ian M; Rayl, Mariah L; Voss, Andrew H; Hughes, Travis S.

Afiliação

Nemetchek MD; Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812.
Chrisman IM; Biochemistry and Biophysics Graduate program, University of Montana, Missoula 59812.
Rayl ML; Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812.
Voss AH; Biochemistry and Biophysics Graduate program, University of Montana, Missoula 59812.
Hughes TS; Center for Biomolecular Structure and Dynamics, University of Montana, Missoula 59812.

Proc Natl Acad Sci U S A ; 119(50): e2215333119, 2022 12 13.

Article em En | MEDLINE | ID: mdl-36469765

Assuntos

Diabetes Mellitus Tipo 2; Tiazolidinedionas; Camundongos; Animais; PPAR gama/metabolismo; Diabetes Mellitus Tipo 2/metabolismo; Tiazolidinedionas/farmacologia; Ligação Proteica; Peptídeos/farmacologia; Peptídeos/metabolismo; Ligantes

Palavras-chave

biased agonism; fluorescence anisotropy; functional selectivity; nuclear receptor; selective modulator

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tiazolidinedionas / Diabetes Mellitus Tipo 2 Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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