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Site-Selective Palladium(II)-Catalyzed Methylene C(sp3)-H Diarylation of a Tropane Scaffold.
Zayene, Mayssa; Le Bideau, Franck; Retailleau, Pascal; Jannet, Hichem Ben; Alami, Mouad; Romdhane, Anis; Messaoudi, Samir.
Afiliação
  • Zayene M; Université Paris-Saclay, BioCIS, CNRS, 5 rue J-B Clément, 92296 Châtenay-Malabry cedex, France.
  • Le Bideau F; Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Avenue of Environment, Faculty of Science of Monastir, University of Monastir, 5019 Monastir, Tunisia.
  • Retailleau P; Université Paris-Saclay, BioCIS, CNRS, 5 rue J-B Clément, 92296 Châtenay-Malabry cedex, France.
  • Jannet HB; Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Universite Paris-Saclay, avenue de la terrasse, 91198 Gif-sur-Yvette, France.
  • Alami M; Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Avenue of Environment, Faculty of Science of Monastir, University of Monastir, 5019 Monastir, Tunisia.
  • Romdhane A; Université Paris-Saclay, BioCIS, CNRS, 5 rue J-B Clément, 92296 Châtenay-Malabry cedex, France.
  • Messaoudi S; Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Avenue of Environment, Faculty of Science of Monastir, University of Monastir, 5019 Monastir, Tunisia.
J Org Chem ; 87(24): 16399-16409, 2022 12 16.
Article em En | MEDLINE | ID: mdl-36473230
A series of 2,4-di-arylated tropane derivatives was synthesized through a site-selective palladium-catalyzed ß-C(sp3)-H di-arylation process. This type of structure has been scarcely reported in literature. They nevertheless represent an interesting class of biologically relevant molecules as illustrated by the observed activity at the micromolecular level of eight derivatives toward human colorectal cancer cell line HCT116.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paládio / Tropanos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paládio / Tropanos Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article