Chiral LC-MS/MS method for the simultaneous determination of (R,S)-ketamine, (R,S)-norketamine, and (2R,6R;2S,6S)-hydroxynorketamine in mouse plasma and brain.

Toki, Hidetoh; Yamaguchi, Jun-Ichi; Mizuno-Yasuhira, Akiko; Endo, Hiromi

Toki, Hidetoh; Yamaguchi, Jun-Ichi; Mizuno-Yasuhira, Akiko; Endo, Hiromi.

Afiliação

Toki H; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-cho, Kita-ku, Saitama-shi, Saitama 331-9530, Japan. Electronic address: h-toki@taisho.co.jp.
Yamaguchi JI; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-cho, Kita-ku, Saitama-shi, Saitama 331-9530, Japan.
Mizuno-Yasuhira A; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-cho, Kita-ku, Saitama-shi, Saitama 331-9530, Japan.
Endo H; Drug Metabolism and Pharmacokinetics, Drug Safety and Pharmacokinetics Laboratories Taisho Pharmaceutical Co., Ltd., 1-403, Yoshino-cho, Kita-ku, Saitama-shi, Saitama 331-9530, Japan.

J Pharm Biomed Anal ; 224: 115168, 2023 Feb 05.

Article em En | MEDLINE | ID: mdl-36473323

Assuntos

Ketamina; Camundongos; Animais; Cromatografia Líquida/métodos; Espectrometria de Massas em Tandem/métodos; Encéfalo/metabolismo; Antidepressivos

Palavras-chave

(2R,6R; (R,S)-ketamine; (R,S)-norketamine; 2S,6S)-hydroxynorketamine; Chiral LC-MS/MS; Mice; Pharmacokinetics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ketamina Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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