Nanostructured Heterogeneous Catalysts for Bioorthogonal Reactions.
Angew Chem Int Ed Engl
; 62(10): e202215427, 2023 03 01.
Article
em En
| MEDLINE
| ID: mdl-36479797
ABSTRACT
Bioorthogonal chemistry has inspired a new subarea of chemistry providing a powerful tool to perform novel biocompatible chemospecific reactions in living systems. Following the premise that they do not interfere with biological functions, bioorthogonal reactions are increasingly applied in biomedical research, particularly with respect to genetic encoding systems, fluorogenic reactions for bioimaging, and cancer therapy. This Minireview compiles recent advances in the use of heterogeneous catalysts for bioorthogonal reactions. The synthetic strategies of Pd-, Au-, and Cu-based materials, their applicability in the activation of caged fluorophores and prodrugs, and the possibilities of using external stimuli to release therapeutic substances at a specific location in a diseased tissue are discussed. Finally, we highlight frontiers in the field, identifying challenges, and propose directions for future development in this emerging field.
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01-internacional
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MEDLINE
Assunto principal:
Pró-Fármacos
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Nanoestruturas
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article