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Primary pulmonary T-cell lymphoproliferative disorders with a limited-stage, low proliferative index, and unusual clinical behavior: two cases of a rare occurrence.
Sabattini, Elena; Bertuzzi, Clara; Broccoli, Alessandro; Agostinelli, Claudio; Gazzola, Anna; Mannu, Claudia; Righi, Simona; Ottaviani, Emanuela; Terragna, Carolina; Motta, Giovanna; Melle, Federica; Ricci, Costantino; Ambrosi, Francesca; Pileri, Stefano A.
Afiliação
  • Sabattini E; Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Via Massarenti 9, 40138, Bologna, Italy. elena.sabattini@aosp.bo.it.
  • Bertuzzi C; Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
  • Broccoli A; IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Istituto Di Ematologia "Seràgnoli", Bologna, Italy.
  • Agostinelli C; Dipartimento Di Medicina Specialistica, Diagnostica E Sperimentale, Università Di Bologna, Bologna, Italy.
  • Gazzola A; Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
  • Mannu C; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
  • Righi S; Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
  • Ottaviani E; Haematopathology Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, Via Massarenti 9, 40138, Bologna, Italy.
  • Terragna C; Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
  • Motta G; IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Istituto Di Ematologia "Seràgnoli", Bologna, Italy.
  • Melle F; IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Istituto Di Ematologia "Seràgnoli", Bologna, Italy.
  • Ricci C; Pathology Unit, Ospedale Maggiore, Bologna, Italy.
  • Ambrosi F; Pathology Unit, Ospedale Maggiore, Bologna, Italy.
  • Pileri SA; Pathology Unit, Ospedale Maggiore, Bologna, Italy.
Virchows Arch ; 482(5): 899-904, 2023 May.
Article em En | MEDLINE | ID: mdl-36480066
Extranodal T-lymphoproliferative disorders or T-cell lymphomas (TLPD) are classified according to the WHO Classification (4th and upcoming 5th editions) (Swerdlow et al., IARC Press 1; Alaggio et al., Leukemia 36(7):1720-1748, 2) and to the International Consensus Classification Update (Campo et al., Blood 140(11):1229-1253, 3) upon several morphologic, phenotypic, and genetic features. None of those at present included has been characterized by primary pulmonary onset. We herein present two such cases which, to the best of our knowledge, have not been previously reported and that might represent another variant of T-cell proliferation at mucosal sites. The two cases share similar histological and phenotypic features, suggesting an origin from CD4 + effector memory T cells with the expression of a CD279/PD-1 antigen. They are both monoclonal, harbor few mutations, and show no disease progression outside the lung. They only differ concerning the local extension of the process and clinical setting. The two cases are examples of so far unreported primary pulmonary TLDP, with limited stage and low proliferative index. A possible relationship with a local yet unknown inflammatory trigger that might have favored the development of the T-cell clone cannot be ruled out.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma de Células T / Transtornos Linfoproliferativos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma de Células T / Transtornos Linfoproliferativos Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article