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Dothideomins A-D, Antibacterial Polycyclic Bisanthraquinones from the Endophytic Fungus Dothideomycetes sp. BMC-101.
Wang, Lusheng; Zong, Shikun; Wang, Haotian; Wu, Chengzhu; Wu, Guangwei; Li, Feng; Yu, Guihong; Li, Dehai; Zhu, Meilin.
Afiliação
  • Wang L; School of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, People's Republic of China.
  • Zong S; School of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, People's Republic of China.
  • Wang H; School of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, People's Republic of China.
  • Wu C; School of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, People's Republic of China.
  • Wu G; College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, People's Republic of China.
  • Li F; Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, United States.
  • Yu G; School of Life Sciences, Shandong Province Key Laboratory of Applied Mycology, Qingdao International Center on Microbes Utilizing Biogas, Qingdao Agricultural University, Qingdao 266109, People's Republic of China.
  • Li D; Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
  • Zhu M; School of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, People's Republic of China.
J Nat Prod ; 85(12): 2789-2795, 2022 12 23.
Article em En | MEDLINE | ID: mdl-36480660
Four new bisanthraquinones, dothideomins A-D (1-4), were identified from Dothideomycetes sp. BMC-101, an endophytic fungus isolated from Magnolia grandiflora L. leaves. Their chemical structures were established by NMR analysis, single-crystal X-ray crystallography, and ECD analysis. Dothideomins A-D (1-4) were characterized by an unusual 6/6/6/5/6/3/6/6 octocyclic scaffold (1 and 2) and a 6/6/6/5/6/6/6 heptacyclic scaffold (3 and 4), respectively. All compounds, especially 1 and 3, exhibited potent antibacterial activity with MIC values ranging from 0.4 to 0.8 µg/mL.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Antibacterianos Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ascomicetos / Antibacterianos Idioma: En Ano de publicação: 2022 Tipo de documento: Article