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Safety and Immunogenicity of a ChAd155-Vectored Respiratory Syncytial Virus (RSV) Vaccine in Healthy RSV-Seropositive Children 12-23 Months of Age.
Díez-Domingo, Javier; Sáez-Llorens, Xavier; Rodriguez-Weber, Miguel A; Epalza, Cristina; Chatterjee, Archana; Chiu, Cheng-Hsun; Lin, Chien-Yu; Berry, Andrea A; Martinón-Torres, Federico; Baquero-Artigao, Fernando; Langley, Joanne M; Ramos Amador, José T; Domachowske, Joseph B; Huang, Li-Min; Chiu, Nan-Chang; Esposito, Susanna; Moris, Philippe; Lien-Anh Nguyen, Thi; Nikic, Vanja; Woo, Wayne; Zhou, Yingjun; Dieussaert, Ilse; Leach, Amanda; Gonzalez Lopez, Antonio; Vanhoutte, Nicolas.
Afiliação
  • Díez-Domingo J; Vaccine Research Department, FISABIO Public Health, Valencia, Spain.
  • Sáez-Llorens X; Department of Infectious Diseases, Hospital del Niño Dr José Renán Esquivel and Cevaxin Clinical Research Center, Panama City, Panama.
  • Rodriguez-Weber MA; National Investigation System, Senacyt, Panama City, Panama.
  • Epalza C; Department of Neonatology, Instituto Nacional de Pediatría, Mexico City, Mexico.
  • Chatterjee A; Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Chiu CH; Research and Clinical Trials Unit, Madrid, Spain.
  • Lin CY; Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre, Madrid, Spain.
  • Berry AA; RITIP (Traslational Research Network in Pediatric Infectious Diseases), Fundación para la Investigación Biomédica del Hospital 12 de Octubre, Madrid, Spain.
  • Martinón-Torres F; Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.
  • Baquero-Artigao F; Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University Taoyuan, Taoyuan, Taiwan.
  • Langley JM; Department of Pediatrics, Hsinchu Mackay Memorial Hospital, Hsinchu City, Taiwan.
  • Ramos Amador JT; Department of Pediatrics and Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA.
  • Domachowske JB; Translational Pediatrics and Infectious Diseases, Pediatrics Department, Hospital Clínico Universitario de Santiago, Santiago de Compostela, Spain.
  • Huang LM; Genetics, Vaccines, Infectious Diseases and Pediatrics Research Group, Spain, Instituto de Investigación Sanitaria de Santiago, Universidad de Santiago de Compostela, Galicia, Spain.
  • Chiu NC; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.
  • Esposito S; Hospital Universitario Infantil La Paz, Department of Infectious Diseases and Tropical Pediatrics, Spain; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.
  • Moris P; CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain.
  • Lien-Anh Nguyen T; Canadian Center for Vaccinology, Iwk Health Centre and Nova Scotia Health Authority, Dalhousie University, Halifax, Canada.
  • Nikic V; Departamento De Salud Pública Y Materno-infantil, Hospital Universitario Clínico San Carlos, Madrid, Spain.
  • Woo W; Department of Pediatrics, SUNY Upstate Medical University, Syracuse, New York, USA.
  • Zhou Y; Department of Pediatrics, National Taiwan University Hospital, Taipei City, Taiwan.
  • Dieussaert I; Department of Pediatrics, Mackay Memorial Hospital, Taipei City, Taiwan.
  • Leach A; Pietro Barilla Children's Hospital, University of Parma, Pediatric Clinic, Parma, Italy.
  • Gonzalez Lopez A; GSK, Rixensart, Belgium.
  • Vanhoutte N; GSK, Wavre, Belgium.
J Infect Dis ; 227(11): 1293-1302, 2023 05 29.
Article em En | MEDLINE | ID: mdl-36484484
Respiratory syncytial virus (RSV) is among the main causes of bronchiolitis and pneumonia regularly leading to hospitalization in children. A safe and effective vaccine to prevent RSV infection in this age group has not yet been found, despite great efforts over several decades. This study tested a new candidate RSV vaccine, expressing 3 important pieces of the virus, in toddlers who already had a previous RSV infection. The vaccine was generally well tolerated. Vaccination triggered antibodies against RSV that were able to block the virus in laboratory tests and that persisted for 1 year.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Sincicial Respiratório Humano / Infecções por Vírus Respiratório Sincicial / Vacinas contra Vírus Sincicial Respiratório Tipo de estudo: Clinical_trials Limite: Humans / Infant Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vírus Sincicial Respiratório Humano / Infecções por Vírus Respiratório Sincicial / Vacinas contra Vírus Sincicial Respiratório Tipo de estudo: Clinical_trials Limite: Humans / Infant Idioma: En Ano de publicação: 2023 Tipo de documento: Article