Your browser doesn't support javascript.
loading
Cardiac MRI in midterm follow-up of MISC: a multicenter study.
Benvenuto, Simone; Simonini, Gabriele; Della Paolera, Sara; Abu Rumeileh, Sarah; Mastrolia, Maria Vincenza; Manerba, Alessandra; Chicco, Daniela; Belgrano, Manuel; Caiffa, Thomas; Cattalini, Marco; Taddio, Andrea.
Afiliação
  • Benvenuto S; University of Trieste, Via dell'Istria 65/1, Trieste, Italy. simone.benvenuto2@icloud.com.
  • Simonini G; NEUROFARBA Department, Rheumatology Unit, Anna Meyer Children's Hospital, University of Florence, Florence, Italy.
  • Della Paolera S; Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
  • Abu Rumeileh S; Rheumatology Unit, Meyer Children's Hospital, University of Florence, Florence, Italy.
  • Mastrolia MV; NEUROFARBA Department, Rheumatology Unit, Anna Meyer Children's Hospital, University of Florence, Florence, Italy.
  • Manerba A; Pediatric Cardiology, ASST Spedali Civili Di Brescia, Brescia, Italy.
  • Chicco D; Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
  • Belgrano M; Department of Radiology, Azienda Sanitaria Universitaria Giuliano Isontina and University of Trieste, Trieste, Italy.
  • Caiffa T; Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.
  • Cattalini M; Pediatric Clinic, University of Brescia, ASST Spedali Civili Di Brescia, Brescia, Italy.
  • Taddio A; University of Trieste, Via dell'Istria 65/1, Trieste, Italy.
Eur J Pediatr ; 182(2): 845-854, 2023 Feb.
Article em En | MEDLINE | ID: mdl-36484863
In this multicenter retrospective study we aimed to evaluate the outcome of cardiac involvement in children affected by multisystem inflammatory syndrome (MIS-C), assessed through cardiac magnetic resonance (CMR). Children referring to three Italian tertiary pediatric centers between February 2020 and November 2021 with a diagnosis of MIS-C, who underwent CMR during a follow-up visit, were enrolled. Demographic, clinical, laboratory, treatment, and outcome data were collected. Twenty MIS-C patients (aged 9-17, median 12 years) were included in the study. Heart involvement at onset was testified by hypotension/shock (55%), laboratory evidence of myocardial involvement (100%), reduced LV ejection fraction (EF) on echocardiography (83%), and/or need for inotrope agents (40%); they all presented good clinical, laboratory, and echocardiographic response to treatment. CMR was performed after a median interval of 3 months from discharge. Pericardial effusion and myocardial edema were found in 5% of patients. Mild residual left ventricular (LV) dysfunction was found in 20% of patients, all showing normal echocardiographic LVEF at discharge. Minimal myocardial scars were found in 25% by late gadolinium enhancement (LGE). One patient was evaluated at two consecutive time points, showing partial resolution of a myocardial scar after 7 months from its first finding. CONCLUSION: Despite the severity of heart involvement in the acute MIS-C phase, the mid-term cardiac outcome is good. Direct cardiac tissue viral invasion may be involved in MIS-C pathogenesis. WHAT IS KNOWN: • Heart involvement is common in MIS-C, but conflicting findings have been shown regarding cardiac outcome when assessed through cardiac MRI. WHAT IS NEW: • Midterm cardiac MRI shows mild abnormalities in patients recovered from MIS-C with any grade of severity of cardiac involvement at presentation.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Ventricular Esquerda / Meios de Contraste Tipo de estudo: Clinical_trials / Observational_studies Limite: Child / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Disfunção Ventricular Esquerda / Meios de Contraste Tipo de estudo: Clinical_trials / Observational_studies Limite: Child / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article