IL-1ß, an important cytokine affecting Helicobacter pylori-mediated gastric carcinogenesis.
Microb Pathog
; 174: 105933, 2023 Jan.
Article
em En
| MEDLINE
| ID: mdl-36494022
ABSTRACT
Infection with Helicobacter pylori (H. pylori) is prevalent around the world and responsible for gastric cancer (GC). The development of GC from gastritis is closely associated with the bacterial virulence and the body's immune response ability. In this process, interleukin-1ß (IL-1ß) plays an important role. Under H. pylori infection, IL-1ß is highly expressed that result in gastric acid inhibition, GC-related gene methylations and disfunctions, angiogenesis. Nod-like receptor pyrin domain containing 3 (NLRP3) inflammasome mediates IL-1ß maturation in cells such as macrophages, neutrophils and dendritic cells. But how does IL-1ß get released across the cell membrane still unclear. In this review, we focus on the secretion mechanism of IL-1ß across the membrane, and to explore the role of IL-1ß in the progression of GC.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Helicobacter pylori
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Infecções por Helicobacter
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article