Selective posttranslational inhibition of Ca<sub>V</sub>ß<sub>1</sub>-associated voltage-dependent calcium channels with a functionalized nanobody.

Morgenstern, Travis J; Nirwan, Neha; Hernández-Ochoa, Erick O; Bibollet, Hugo; Choudhury, Papiya; Laloudakis, Yianni D; Ben Johny, Manu; Bannister, Roger A; Schneider, Martin F; Minor, Daniel L; Colecraft, Henry M

Selective posttranslational inhibition of Ca_Vß₁-associated voltage-dependent calcium channels with a functionalized nanobody.

Morgenstern, Travis J; Nirwan, Neha; Hernández-Ochoa, Erick O; Bibollet, Hugo; Choudhury, Papiya; Laloudakis, Yianni D; Ben Johny, Manu; Bannister, Roger A; Schneider, Martin F; Minor, Daniel L; Colecraft, Henry M.

Afiliação

Morgenstern TJ; Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical Center, New York, NY, USA.
Nirwan N; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.
Hernández-Ochoa EO; Department of Biochemistry and Biology, University of Maryland School of Medicine, Baltimore, MD, USA.
Bibollet H; Department of Biochemistry and Biology, University of Maryland School of Medicine, Baltimore, MD, USA.
Choudhury P; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Laloudakis YD; Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Ben Johny M; Department of Physiology and Cellular Biophysics, Columbia University Irving Medical Center, New York, NY, USA.
Bannister RA; Department of Biochemistry and Biology, University of Maryland School of Medicine, Baltimore, MD, USA.
Schneider MF; Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA.
Minor DL; Department of Biochemistry and Biology, University of Maryland School of Medicine, Baltimore, MD, USA.
Colecraft HM; Cardiovascular Research Institute, University of California, San Francisco, CA, USA.

Nat Commun ; 13(1): 7556, 2022 Dec 09.

Article em En | MEDLINE | ID: mdl-36494348

Assuntos

Canais de Cálcio; Miócitos Cardíacos; Canais de Cálcio/metabolismo; Miócitos Cardíacos/metabolismo; Neurônios/metabolismo; Domínios de Homologia de src; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Canais de Cálcio Tipo L/genética; Canais de Cálcio Tipo L/metabolismo; Cálcio/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Canais de Cálcio / Miócitos Cardíacos Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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