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RNAi machinery regulates nutrient metabolism and fluconazole resistance in the pathogenic fungus Cryptococcus deneoformans.
Ma, Xiaoyu; Li, Chenxi; Ma, Lan; Zhao, Xuan; Liu, Yanjie; Hao, Xiaoran; Zhang, Ping; Zhu, Xudong.
Afiliação
  • Ma X; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
  • Li C; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
  • Ma L; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
  • Zhao X; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
  • Liu Y; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
  • Hao X; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
  • Zhang P; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
  • Zhu X; Beijing Key Laboratory of Genetic Engineering Drug and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing 100875, China.
Med Mycol ; 61(2)2023 Feb 03.
Article em En | MEDLINE | ID: mdl-36496203
Transcriptome sequencing reveals biological functions of RNAi in C. deneoformans. Nutritional metabolism is deficient due to the AGO2 disruption. RNAi mechanism inhibits fluconazole resistance by regulating the expression of transporters.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Criptococose / Cryptococcus neoformans Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Criptococose / Cryptococcus neoformans Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article