Mechanistic insights into the nickel-dependent allosteric response of the Helicobacter pylori NikR transcription factor.

Baksh, Karina A; Augustine, Jerry; Sljoka, Adnan; Prosser, R Scott; Zamble, Deborah B

Baksh, Karina A; Augustine, Jerry; Sljoka, Adnan; Prosser, R Scott; Zamble, Deborah B.

Afiliação

Baksh KA; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada.
Augustine J; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
Sljoka A; RIKEN Center for Advanced Intelligence Project, RIKEN, Chuo-ku, Tokyo, Japan. Electronic address: adnan.sljoka@riken.jp.
Prosser RS; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada. Electronic address: scott.prosser@utoronto.ca.
Zamble DB; Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.

J Biol Chem ; 299(1): 102785, 2023 01.

Article em En | MEDLINE | ID: mdl-36502919

Assuntos

Proteínas de Bactérias; Helicobacter pylori; Níquel; Proteínas Repressoras; Humanos; Proteínas de Bactérias/metabolismo; Helicobacter pylori/metabolismo; Níquel/metabolismo; Proteínas Repressoras/metabolismo; Fatores de Transcrição/metabolismo

Palavras-chave

DNA-binding protein; DNA-protein interaction; allosteric regulation; bacterial transcription; computational biology; metal homeostasis; metalloprotein; nickel; structure-function; transcription factor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Repressoras / Proteínas de Bactérias / Helicobacter pylori / Níquel Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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