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Characterization of material properties and deformation in the ANGUS phantom during mild head impacts using MRI.
Knutsen, Andrew K; Vidhate, Suhas; McIlvain, Grace; Luster, Josh; Galindo, Eric J; Johnson, Curtis L; Pham, Dzung L; Butman, John A; Mejia-Alvarez, Ricardo; Tartis, Michaelann; Willis, Adam M.
Afiliação
  • Knutsen AK; Center for Neuroscience and Regenerative Medicine, The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20814, USA.
  • Vidhate S; Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, 20892, USA. Electronic address: suhas.vidhate.msu@gmail.com.
  • McIlvain G; Department of Biomedical Engineering, University of Delaware, Newark, DE, 19716, USA.
  • Luster J; Department of Neurology, Brooke Army Medical Center, Fort Sam Houston, TX, 78234, USA.
  • Galindo EJ; Department of Chemical Engineering, New Mexico Institute of Mining and Technology, Socorro, NM, 87801, USA.
  • Johnson CL; Department of Biomedical Engineering, University of Delaware, Newark, DE, 19716, USA.
  • Pham DL; Center for Neuroscience and Regenerative Medicine, The Henry M Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, 20814, USA.
  • Butman JA; Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, 20892, USA.
  • Mejia-Alvarez R; Department of Mechanical Engineering, Michigan State University, East Lansing, MI, 48824, USA.
  • Tartis M; Department of Chemical Engineering, New Mexico Institute of Mining and Technology, Socorro, NM, 87801, USA.
  • Willis AM; Department of Mechanical Engineering, Michigan State University, East Lansing, MI, 48824, USA; 59th Medical Wing, Office of the Chief Scientist, Lackland AFB, TX, 78236, USA.
J Mech Behav Biomed Mater ; 138: 105586, 2023 02.
Article em En | MEDLINE | ID: mdl-36516544
Traumatic brain injury (TBI) is a major health concern affecting both military and civilian populations. Despite notable advances in TBI research in recent years, there remains a significant gap in linking the impulsive loadings from a blast or a blunt impact to the clinical injury patterns observed in TBI. Synthetic head models or phantoms can be used to establish this link as they can be constructed with geometry, anatomy, and material properties that match the human brain, and can be used as an alternative to animal models. This study presents one such phantom called the Anthropomorphic Neurologic Gyrencephalic Unified Standard (ANGUS) phantom, which is an idealized gyrencephalic brain phantom composed of polyacrylamide gel. Here we mechanically characterized the ANGUS phantom using tagged magnetic resonance imaging (MRI) and magnetic resonance elastography (MRE), and then compared the outcomes to data obtained in healthy volunteers. The direct comparison between the phantom's response and the data from a cohort of in vivo human subjects demonstrate that the ANGUS phantom may be an appropriate model for bulk tissue response and gyral dynamics of the human brain under small amplitude linear impulses. However, the phantom's response differs from that of the in vivo human brain under rotational impacts, suggesting avenues for future improvements to the phantom.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Lesões Encefálicas Traumáticas Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Lesões Encefálicas Traumáticas Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article