Establishment and validation of a risk prediction model for high-grade cervical lesions.
Eur J Obstet Gynecol Reprod Biol
; 281: 1-6, 2023 Feb.
Article
em En
| MEDLINE
| ID: mdl-36521399
ABSTRACT
OBJECTIVE:
To establish and validate a risk prediction model for cervical high-grade squamous intraepithelial lesions (HSIL).METHODS:
This retrospective study included patients who underwent cervical biopsies at the Cervical Disease Centre of Maternal and Child Hospital of Hubei Province between January 2021 and December 2021.RESULTS:
A total of 1630 patients were divided into the HSIL + cervical lesion group (n = 186) and the ≤ LSIL cervical lesions group (n = 1444). LSIL, ASC-H, HSIL and SCC, high-risk HPV, HPV16, HPV18/45, multiple HPV strains, acetowhite epithelium, atypical vessels, and mosaicity were independently associated with HSIL + lesions. These factors were used to establish a risk prediction model with a demonstrated area under the curve (AUC) of 0.851 and a C-index of 0.829. Calibration curve analysis showed that the model performed well, with a mean absolute error (MAE) of 0.005. The decision curve showed that the model created by combining the risk factors was more specific and sensitive than each predictive variable.CONCLUSION:
The model for predicting HSIL demonstrated promising predictive capability and might help identify patients requiring biopsy and treatment.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Displasia do Colo do Útero
/
Neoplasias do Colo do Útero
/
Infecções por Papillomavirus
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Child
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Female
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Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article