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Emraclidine, a novel positive allosteric modulator of cholinergic M4 receptors, for the treatment of schizophrenia: a two-part, randomised, double-blind, placebo-controlled, phase 1b trial.
Krystal, John H; Kane, John M; Correll, Christoph U; Walling, David P; Leoni, Matthew; Duvvuri, Sridhar; Patel, Shrinal; Chang, Ih; Iredale, Philip; Frohlich, Lillian; Versavel, Stacey; Perry, Pamela; Sanchez, Raymond; Renger, John.
Afiliação
  • Krystal JH; Yale Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
  • Kane JM; Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA; Department of Psychiatry and Medicine, The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
  • Correll CU; Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, NY, USA; Department of Psychiatry and Medicine, The Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA; Department of Child and Adolescent Psychiatry, Charité University Medicine, Berlin, Germany.
  • Walling DP; CNS Network, Garden Grove, CA, USA.
  • Leoni M; Cerevel Therapeutics, Cambridge, MA, USA.
  • Duvvuri S; Cerevel Therapeutics, Cambridge, MA, USA.
  • Patel S; Cerevel Therapeutics, Cambridge, MA, USA.
  • Chang I; Cerevel Therapeutics, Cambridge, MA, USA.
  • Iredale P; Cerevel Therapeutics, Cambridge, MA, USA. Electronic address: philip.iredale@cerevel.com.
  • Frohlich L; Cerevel Therapeutics, Cambridge, MA, USA.
  • Versavel S; Cerevel Therapeutics, Cambridge, MA, USA.
  • Perry P; Cerevel Therapeutics, Cambridge, MA, USA.
  • Sanchez R; Cerevel Therapeutics, Cambridge, MA, USA.
  • Renger J; Cerevel Therapeutics, Cambridge, MA, USA.
Lancet ; 400(10369): 2210-2220, 2022 12 17.
Article em En | MEDLINE | ID: mdl-36528376
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia Tipo de estudo: Clinical_trials / Guideline Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia Tipo de estudo: Clinical_trials / Guideline Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article