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Discovery of RMC-5552, a Selective Bi-Steric Inhibitor of mTORC1, for the Treatment of mTORC1-Activated Tumors.
Burnett, G Leslie; Yang, Yu C; Aggen, James B; Pitzen, Jennifer; Gliedt, Micah K; Semko, Chris M; Marquez, Abby; Evans, James W; Wang, Gang; Won, Walter S; Tomlinson, Aidan C A; Kiss, Gert; Tzitzilonis, Christos; Thottumkara, Arun P; Cregg, James; Mellem, Kevin T; Choi, Jong S; Lee, Julie C; Zhao, Yongyuan; Lee, Bianca J; Meyerowitz, Justin G; Knox, John E; Jiang, Jingjing; Wang, Zhican; Wildes, David; Wang, Zhengping; Singh, Mallika; Smith, Jacqueline A M; Gill, Adrian L.
Afiliação
  • Burnett GL; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Yang YC; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Aggen JB; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Pitzen J; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Gliedt MK; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Semko CM; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Marquez A; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Evans JW; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Wang G; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Won WS; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Tomlinson ACA; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Kiss G; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Tzitzilonis C; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Thottumkara AP; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Cregg J; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Mellem KT; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Choi JS; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Lee JC; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Zhao Y; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Lee BJ; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Meyerowitz JG; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Knox JE; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Jiang J; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Wang Z; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Wildes D; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Wang Z; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Singh M; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Smith JAM; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
  • Gill AL; Revolution Medicines, Incorporated, Redwood City, California 94063, United States.
J Med Chem ; 66(1): 149-169, 2023 01 12.
Article em En | MEDLINE | ID: mdl-36533617
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article