Optimization of 4D combined angiography and perfusion using radial imaging and arterial spin labeling.
Magn Reson Med
; 89(5): 1853-1870, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-36533868
ABSTRACT
PURPOSE:
To extend and optimize a non-contrast MRI technique to obtain whole head 4D (time-resolved 3D) qualitative angiographic and perfusion images from a single scan.METHODS:
4D combined angiography and perfusion using radial imaging and arterial spin labeling (CAPRIA) uses pseudocontinuous labeling with a 3D golden ratio ("koosh ball") readout to continuously image the blood water as it travels through the arterial system and exchanges into the tissue. High spatial/temporal resolution angiograms and low spatial/temporal resolution perfusion images can be flexibly reconstructed from the same raw k-space data. Constant and variable flip angle (CFA and VFA, respectively) excitation schedules were optimized through simulations and tested in healthy volunteers. A conventional sensitivity encoding (SENSE) reconstruction was compared against a locally low rank (LLR) reconstruction, which leverages spatiotemporal correlations. Comparison was also made with time-matched time-of-flight angiography and multi-delay EPI perfusion images. Differences in image quality were assessed through split-scan repeatability.RESULTS:
The optimized VFA schedule (2-9°) resulted in a significant (p < 0.001) improvement in image quality (up to 84% vs. CFA), particularly for the lower SNR perfusion images. The LLR reconstruction provided effective denoising without biasing the signal timecourses, significantly improving angiographic and perfusion image quality and repeatability (up to 143%, p < 0.001). 4D CAPRIA performed well compared with time-of-flight angiography and had better perfusion signal repeatability than the EPI-based approach (p < 0.001).CONCLUSION:
4D CAPRIA optimized using a VFA schedule and LLR reconstruction can yield high quality whole head 4D angiograms and perfusion images from a single scan.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Angiografia por Ressonância Magnética
/
Imageamento Tridimensional
Tipo de estudo:
Qualitative_research
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article