Enhanced Therapeutic Effect of Optimized Melittin-dKLA, a Peptide Agent Targeting M2-like Tumor-Associated Macrophages in Triple-Negative Breast Cancer.

Kim, Soyoung; Choi, Ilseob; Han, Ik-Hwan; Bae, Hyunsu

Kim, Soyoung; Choi, Ilseob; Han, Ik-Hwan; Bae, Hyunsu.

Afiliação

Kim S; Department of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Choi I; Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Han IH; Department of Physiology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Bae H; Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.

Int J Mol Sci ; 23(24)2022 Dec 12.

Article em En | MEDLINE | ID: mdl-36555393

Assuntos

Neoplasias de Mama Triplo Negativas; Macrófagos Associados a Tumor; Humanos; Animais; Camundongos; Macrófagos Associados a Tumor/metabolismo; Neoplasias de Mama Triplo Negativas/patologia; Meliteno/farmacologia; Meliteno/uso terapêutico; Peptídeos/metabolismo; Macrófagos/metabolismo; Microambiente Tumoral; Linhagem Celular Tumoral

Palavras-chave

PEG-melittin-dKLA 8-26; cancer immunotherapy; melittin-dKLA; triple-negative breast cancer; tumor microenvironment; tumor-associated macrophages

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias de Mama Triplo Negativas / Macrófagos Associados a Tumor Tipo de estudo: Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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