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Engineered Human Antibody with Improved Endothelin Receptor Type A Binding Affinity, Developability, and Serum Persistence Exhibits Excellent Antitumor Potency.
Ko, Sanghwan; Ju, Man-Seok; Ahn, Hye-Mi; Na, Jung-Hyun; Ko, Woo Hyung; Jo, Migyeong; Kyung, Munsu; Lim, Chung Su; Ko, Byoung Joon; Lee, Won-Kyu; Kim, Youn-Jae; Jung, Sang Taek.
Afiliação
  • Ko S; Department of Biomedical Sciences, Graduate School, Korea University, Seoul 02841, Republic of Korea.
  • Ju MS; Institute of Human Genetics, Korea University College of Medicine, Seoul 02841, Republic of Korea.
  • Ahn HM; Department of Biomedical Sciences, Graduate School, Korea University, Seoul 02841, Republic of Korea.
  • Na JH; Institute of Human Genetics, Korea University College of Medicine, Seoul 02841, Republic of Korea.
  • Ko WH; Targeted Therapy Branch, Division of Rare and Refractory Cancer, Research Institute, National Cancer Center, Goyang, Gyeonggi-do 10408, Republic of Korea.
  • Jo M; Department of Pharmaceutical Engineering, Sangji University, Wonju, Gangwon-do 26339, Republic of Korea.
  • Kyung M; Department of Biomedical Sciences, Graduate School, Korea University, Seoul 02841, Republic of Korea.
  • Lim CS; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Republic of Korea.
  • Ko BJ; Department of Biomedical Sciences, Graduate School, Korea University, Seoul 02841, Republic of Korea.
  • Lee WK; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Republic of Korea.
  • Kim YJ; Department of Biomedical Sciences, Graduate School, Korea University, Seoul 02841, Republic of Korea.
  • Jung ST; BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul 02841, Republic of Korea.
Mol Pharm ; 20(2): 1247-1255, 2023 02 06.
Article em En | MEDLINE | ID: mdl-36563318
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Engenharia de Proteínas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Engenharia de Proteínas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article