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Effects of Intensive Blood Glucose Control on Surgical Site Infection for Liver Transplant Recipients: A Randomized Controlled Trial.
Oliveira, Ramon Antônio; Tanner, Judith; Mancero, Jorge Marcelo Padilla; de Brito Poveda, Vanessa.
Afiliação
  • Oliveira RA; Universidade De São Paulo, Escola De Enfermagem, São Paulo, Brazil. Electronic address: Ramon.Oliveira@Alumni.Usp.Br.
  • Tanner J; Faculty of Medicine and Health Sciences, University of Nottingham, The Queen's Medical Centre, Nottingham, United Kingdom.
  • Mancero JMP; Hospital da Santa Casa de São José dos Campos, São José dos Campos, Brazil.
  • de Brito Poveda V; Universidade De São Paulo, Escola De Enfermagem, São Paulo, Brazil.
Transplant Proc ; 55(1): 170-177, 2023.
Article em En | MEDLINE | ID: mdl-36567173
BACKGROUND: The evidence supporting intensive blood glucose control to prevent surgical site infections (SSIs) among liver transplant recipients is insufficient. We aimed to assess the effects of postoperative intensive blood glucose control (IBGC) against standard blood glucose control (SBGC) on the incidence of SSIs among adult liver transplant recipients. METHODS: We performed a randomized controlled trial (ClinicalTrials.gov identifier NCT03474666). The IBGC target was 80 to 130 mg/dL, and the SBGC target was below 180 mg/dL. Analyses were made on an intention-to-treat basis. RESULTS: Of the 41 recipients enrolled onto the trial, 20 were randomly allocated to the IBGC group and 21 to the SBGC group. There were no significant differences in SSIs among recipients allocated to either group (relative risk [RR], 0.78; 95% confidence interval [CI], 0.21-2.88; P = .69). Mean (SD) blood glucose levels were significantly lower in the IBGC group in the 24-hour period after surgery (145.0 [20.7] mg/dL and 230.2 [51.6] mg/dL; P = .001). While there were fewer episodes of hypoglycemia in the IBGC group, this was not statistically significant. There were no episodes of severe hypoglycemia in either group. Hyperglycemia and severe hyperglycemia were significantly more frequent in the SBGC group (RR, 0.70; 95% CI, 0.52-0.93; P = .001 and RR, 0.07; 95% CI, 0.01-0.48; P = .001, respectively). Length of hospital stay was significantly shorter for recipients in the IBGC group (13.1 [5.5] days vs 19.3 [12.1] days; P = .04). CONCLUSIONS: Although this small trial did not find intensive control reduced SSI, it was associated with lower blood glucose levels, fewer episodes of hyperglycemia and severe hyperglycemia, and shorter length of hospital stay.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Diabetes Mellitus / Hiperglicemia / Hipoglicemia Tipo de estudo: Clinical_trials / Etiology_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transplante de Fígado / Diabetes Mellitus / Hiperglicemia / Hipoglicemia Tipo de estudo: Clinical_trials / Etiology_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article