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Increased formation of neutrophil extracellular traps in patients with anti-N-methyl-d-aspartate receptor encephalitis.
Qiao, Shan; Sun, Quan-Ye; Zhou, Peng; Zhang, Shan-Chao; Wang, Zhi-Hao; Li, Hai-Yun; Wang, Ai-Hua; Liu, Xue-Wu; Xin, Tao.
Afiliação
  • Qiao S; Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
  • Sun QY; Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
  • Zhou P; Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
  • Zhang SC; Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
  • Wang ZH; School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Li HY; Department of Neurology, Qilu Hospital of Shandong University, Jinan, China.
  • Wang AH; Department of Neurology, Qilu Hospital of Shandong University, Jinan, China.
  • Liu XW; Department of Neurology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, China.
  • Xin T; Department of Neurology, Qilu Hospital of Shandong University, Jinan, China.
Front Immunol ; 13: 1046778, 2022.
Article em En | MEDLINE | ID: mdl-36569875
Background: Neutrophil extracellular traps (NETs) have been found to play an important role in several nervous system diseases. However, their role in anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis remains unclear. The purpose of this study was to examine the possible role of NETs in anti-NMDAR encephalitis. Materials and methods: Eleven patients with anti-NMDAR encephalitis and ten healthy participants were enrolled. Plasma NETs levels were detected using an immunofluorescence assay and enzyme-linked immunosorbent assay. Additionally, we examined 10 plasma cytokines in patients with anti-NMDAR encephalitis and analyzed the correlation between citrullinated histone 3 levels and cytokine release. Results: Peripheral blood neutrophils from patients with anti-NMDAR encephalitis were more susceptible to NET generation. When compared with controls, cases of anti-NMDAR encephalitis showed elevated levels of IL-1 α, IL-6, IL-8, IL-13, MCP-1, and TNF-α (p < 0.05). Moreover, IL-6, IL-8, and TNF-α levels were positively correlated with H3Cit levels. Conclusion: We provide evidence that NETs may play a role in anti-NMDAR encephalitis, providing clues for elucidation of the pathogenesis of this disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalite Antirreceptor de N-Metil-D-Aspartato / Armadilhas Extracelulares Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encefalite Antirreceptor de N-Metil-D-Aspartato / Armadilhas Extracelulares Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article