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Association of daily physical activity with brain volumes and cervical spinal cord areas in multiple sclerosis.
Block, Valerie J; Cheng, Shuiting; Juwono, Jeremy; Cuneo, Richard; Kirkish, Gina; Alexander, Amber M; Khan, Mahir; Akula, Amit; Caverzasi, Eduardo; Papinutto, Nico; Stern, William A; Pletcher, Mark J; Marcus, Gregory M; Olgin, Jeffrey E; Hauser, Stephen L; Gelfand, Jeffrey M; Bove, Riley; Cree, Bruce Ac; Henry, Roland G.
Afiliação
  • Block VJ; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA/Department of Physical Therapy and Rehabilitation Science, University of California San Francisco, San Francisco, CA, USA.
  • Cheng S; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Juwono J; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Cuneo R; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Kirkish G; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Alexander AM; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Khan M; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Akula A; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Caverzasi E; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA/Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
  • Papinutto N; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Stern WA; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Pletcher MJ; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA/Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
  • Marcus GM; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
  • Olgin JE; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
  • Hauser SL; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Gelfand JM; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Bove R; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Cree BA; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA.
  • Henry RG; UCSF Weill Institute for Neurosciences, Department of Neurology, University of California San Francisco, San Francisco, CA, USA/Department of Radiology, University of California San Francisco, San Francisco, CA, USA.
Mult Scler ; 29(3): 363-373, 2023 03.
Article em En | MEDLINE | ID: mdl-36573559
ABSTRACT

BACKGROUND:

Remote activity monitoring has the potential to evaluate real-world, motor function, and disability at home. The relationships of daily physical activity with spinal cord white matter and gray matter (GM) areas, multiple sclerosis (MS) disability and leg function, are unknown.

OBJECTIVE:

Evaluate the association of structural central nervous system pathology with ambulatory disability.

METHODS:

Fifty adults with progressive or relapsing MS with motor disability who could walk >2 minutes were assessed using clinician-evaluated, patient-reported outcomes, and quantitative brain and spinal cord magnetic resonance imaging (MRI) measures. Fitbit Flex2, worn on the non-dominant wrist, remotely assessed activity over 30 days. Univariate and multivariate analyses were performed to assess correlations between physical activity and other disability metrics.

RESULTS:

Mean age was 53.3 years and median Expanded Disability Status Scale (EDSS) was 4.0. Average daily step counts (STEPS) were highly correlated with EDSS and walking measures. Greater STEPS were significantly correlated with greater C2-C3 spinal cord GM areas (ρ = 0.39, p = 0.04), total cord area (TCA; ρ = 0.35, p = 0.04), and cortical GM volume (ρ = 0.32, p = 0.04).

CONCLUSION:

These results provide preliminary evidence that spinal cord GM area is a neuroanatomical substrate associated with STEPS. STEPS could serve as a proxy to alert clinicians and researchers to possible changes in structural nervous system pathology.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pessoas com Deficiência / Medula Cervical / Transtornos Motores / Esclerose Múltipla Tipo de estudo: Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pessoas com Deficiência / Medula Cervical / Transtornos Motores / Esclerose Múltipla Tipo de estudo: Risk_factors_studies Limite: Adult / Humans / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article