Cell of Origin of Brain and Spinal Cord Tumors.
Adv Exp Med Biol
; 1394: 85-101, 2023.
Article
em En
| MEDLINE
| ID: mdl-36587383
ABSTRACT
A better understanding of cellular and molecular biology of primary central nervous system (CNS) tumors is a critical step toward the design of innovative treatments. In addition to improving knowledge, identification of the cell of origin in tumors allows for sharp and efficient targeting of specific tumor cells promoting and driving oncogenic processes. The World Health Organization identifies approximately 150 primary brain tumor subtypes with various ontogeny and clinical outcomes. Identification of the cell of origin of each tumor type with its lineage and differentiation level is challenging. In the current chapter, we report the suspected cell of origin of various CNS primary tumors including gliomas, glioneuronal tumors, medulloblastoma, meningioma, atypical teratoid rhabdoid tumor, germinomas, and lymphoma. Most of them have been pinpointed through transgenic mouse models and analysis of molecular signatures of tumors. Identification of the cell or cells of origin in primary brain tumors will undoubtedly open new therapeutic avenues, including the reactivation of differentiation programs for therapeutic perspectives.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Medula Espinal
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Neoplasias Encefálicas
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Neoplasias Cerebelares
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Neoplasias do Sistema Nervoso Central
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Tumor Rabdoide
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Glioma
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Meduloblastoma
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article