A multi-scale model explains oscillatory slowing and neuronal hyperactivity in Alzheimer's disease.

Alexandersen, Christoffer G; de Haan, Willem; Bick, Christian; Goriely, Alain

Alexandersen, Christoffer G; de Haan, Willem; Bick, Christian; Goriely, Alain.

Afiliação

Alexandersen CG; Mathematical Institute, University of Oxford, Oxford, UK.
de Haan W; Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Bick C; Mathematical Institute, University of Oxford, Oxford, UK.
Goriely A; Department of Mathematics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

J R Soc Interface ; 20(198): 20220607, 2023 01.

Article em En | MEDLINE | ID: mdl-36596460

Assuntos

Doença de Alzheimer; Conectoma; Humanos; Doença de Alzheimer/metabolismo; Peptídeos beta-Amiloides/metabolismo; Peptídeos beta-Amiloides/farmacologia; Neurônios; Encéfalo/metabolismo

Palavras-chave

Alzheimer's disease; brain dynamics; frequency slowing; network adaptation; neural oscillation; neurodegeneration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Conectoma Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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