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Mouth Level Intake of Nicotine from Three Brands of Little Filtered Cigars with Widely Differing Product Characteristics Among Adult Consumers.
Ashley, David L; Zhu, Wanzhe; Watson, Clifford H; Bravo, Roberto; Ngac, Phuong K; Valentin-Blasini, Liza; Pickworth, Wallace B; Kurti, Allison N; Cunningham, Colin; Blount, Benjamin C.
Afiliação
  • Ashley DL; Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, Georgia 30303, United States.
  • Zhu W; Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, United States Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States.
  • Watson CH; Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, United States Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States.
  • Bravo R; Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, United States Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States.
  • Ngac PK; Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, United States Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States.
  • Valentin-Blasini L; Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, United States Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States.
  • Pickworth WB; Battelle Public Health Research Center, Baltimore, Maryland 21209, United States.
  • Kurti AN; Center for Tobacco Products, United States Food and Drug Administration, Silver Spring, Maryland 20993, United States.
  • Cunningham C; Center for Tobacco Products, United States Food and Drug Administration, Silver Spring, Maryland 20993, United States.
  • Blount BC; Tobacco and Volatiles Branch, Division of Laboratory Sciences, National Center for Environmental Health, United States Centers for Disease Control and Prevention, Atlanta, Georgia 30341, United States.
Chem Res Toxicol ; 36(1): 43-52, 2023 01 16.
Article em En | MEDLINE | ID: mdl-36598842
Little filtered cigars are tobacco products with many cigarette-like characteristics. However, despite cigars falling under the U.S. Food and Drug Administration regulatory authority, characterizing flavors, which are still allowed in little filtered cigars, and filter design may influence how people use the products and the resulting exposure to harmful and potentially harmful constituents. We estimated nicotine mouth level intake (MLI) from analyses of little cigar filter butt solanesol levels, brand characteristics, carbon monoxide boost, and puff volume in 48 dual cigarette/cigar users during two repeat bouts of ad lib smoking of three little filtered cigar brands. Mean nicotine MLI for the three brands was significantly different with Swisher Sweets (0.1% ventilation) Cherry at 1.20 mg nicotine, Cheyenne Menthol (1.5%) at 0.63 mg, and Santa Fe unflavored (49%) at 0.94 mg. The association between nicotine MLI and puff volume was the same between Cheyenne Menthol and Santa Fe unflavored. However, these were different from Swisher Sweets Cherry. At least five main factors─flavor, ventilation, filter design, nicotine delivery related to tar, and user puff volume─may directly or indirectly impact MLI and its association with other measures. We found that users of little filtered cigars that have different filter ventilation and flavor draw dissimilar amounts of nicotine from the product, which may be accompanied by differences in exposure to other harmful smoke constituents.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos do Tabaco / Nicotina Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos do Tabaco / Nicotina Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article