Future regenerative therapies for corneal disease.
Curr Opin Ophthalmol
; 34(3): 267-272, 2023 May 01.
Article
em En
| MEDLINE
| ID: mdl-36602407
ABSTRACT
PURPOSE OF REVIEW To highlight the progress and future direction of stem-cell based regenerative therapies for the treatment of corneal disease. RECENT FINDINGS:
Corneal stem cell-based therapies, such as limbal stem cell transplantation, corneal stromal stem cell transplantation, endothelial stem cell transplantation, and stem cell-derived extracellular vesicles have demonstrated promising results in the laboratory. Although most are still in preclinical development or early phase clinical trials, these stem cell-based therapies hold potential to facilitate tissue regeneration, restore native function, and inhibit pathologic disease processes such as fibrosis, inflammation, and neovascularization.SUMMARY:
Stem cell-based therapy offers a promising therapeutic option that can circumvent several of the challenges and limitations of traditional surgical treatment. This concise review summarizes the progress in stem-cell based therapies for corneal diseases along with their history, underlying mechanisms, limitations, and future areas for development.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transplante de Córnea
/
Limbo da Córnea
/
Epitélio Corneano
/
Doenças da Córnea
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article