Targeting Lin28 axis enhances glypican-3-CAR T cell efficacy against hepatic tumor initiating cell population.

Patra, Tapas; Cunningham, David M; Meyer, Keith; Toth, Karoly; Ray, Ratna B; Heczey, Andras; Ray, Ranjit

Targeting Lin28 axis enhances glypican-3-CAR T cell efficacy against hepatic tumor initiating cell population.

Patra, Tapas; Cunningham, David M; Meyer, Keith; Toth, Karoly; Ray, Ratna B; Heczey, Andras; Ray, Ranjit.

Afiliação

Patra T; Department of Internal Medicine, Saint Louis University, St. Louis, MO 63104, USA. Electronic address: tpatra012@gmail.com.
Cunningham DM; Center for Advanced Innate Cell Therapy, Texas Children's Cancer Center, Division of Pediatric Hematology and Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Meyer K; Department of Internal Medicine, Saint Louis University, St. Louis, MO 63104, USA.
Toth K; Department of Molecular Microbiology & Immunology and Saint Louis University, St. Louis, MO 63104, USA.
Ray RB; Department of Pathology, Saint Louis University, St. Louis, MO 63104, USA.
Heczey A; Center for Advanced Innate Cell Therapy, Texas Children's Cancer Center, Division of Pediatric Hematology and Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Ray R; Department of Internal Medicine, Saint Louis University, St. Louis, MO 63104, USA; Department of Molecular Microbiology & Immunology and Saint Louis University, St. Louis, MO 63104, USA. Electronic address: rayr@slu.edu.

Mol Ther ; 31(3): 715-728, 2023 03 01.

Article em En | MEDLINE | ID: mdl-36609146

Assuntos

Carcinoma Hepatocelular; Neoplasias Hepáticas; Receptores de Antígenos Quiméricos; Humanos; Animais; Camundongos; Carcinoma Hepatocelular/genética; Carcinoma Hepatocelular/terapia; Carcinoma Hepatocelular/metabolismo; Linfócitos T/metabolismo; Receptores de Antígenos Quiméricos/metabolismo; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/terapia; Neoplasias Hepáticas/metabolismo; Antígeno B7-H1/metabolismo; Glipicanas/genética; Cinurenina/metabolismo; Células-Tronco Neoplásicas/metabolismo; Linhagem Celular Tumoral; Indolamina-Pirrol 2,3,-Dioxigenase/genética; Indolamina-Pirrol 2,3,-Dioxigenase/metabolismo

Palavras-chave

CAR T cell; IDO1; Lin28B; PD-L1; glypican-3; hepatocellular carcinoma

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Receptores de Antígenos Quiméricos / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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