Folic acid depletion along with inhibition of the PERK arm of endoplasmic reticulum stress pathway promotes a less aggressive phenotype of hepatocellular carcinoma cells.

Goyal, Himanshi; Sharma, Renuka; Lamba, Dikshit; Kaur, Jyotdeep

Goyal, Himanshi; Sharma, Renuka; Lamba, Dikshit; Kaur, Jyotdeep.

Afiliação

Goyal H; Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Sharma R; Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Lamba D; Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
Kaur J; Department of Biochemistry, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. jyotdeep2001@yahoo.co.in.

Mol Cell Biochem ; 478(9): 2057-2068, 2023 Sep.

Article em En | MEDLINE | ID: mdl-36609634

Assuntos

Carcinoma Hepatocelular; Neoplasias Hepáticas; Humanos; Carcinoma Hepatocelular/metabolismo; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Ácido Fólico/farmacologia; eIF-2 Quinase/genética; eIF-2 Quinase/metabolismo; eIF-2 Quinase/farmacologia; Estresse do Retículo Endoplasmático; Resposta a Proteínas não Dobradas; Apoptose; Fenótipo

Palavras-chave

Apoptosis; Folate deficiency (FD); Folic acid; HepG2 cells; Hepatocellular carcinoma; Invasion; Migration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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