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A Study on the Chemistry and Biological Activity of 26-Sulfur Analogs of Diosgenin: Synthesis of 26-Thiodiosgenin S-Mono- and Dioxides, and Their Alkyl Derivatives.
Tomkiel, Aneta M; Czajkowska-Szczykowska, Dorota; Olchowik-Grabarek, Ewa; Rárová, Lucie; Sekowski, Szymon; Morzycki, Jacek W.
Afiliação
  • Tomkiel AM; Laboratory of Natural Products, Department of Organic Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciolkowskiego 1K, 15-245 Bialystok, Poland.
  • Czajkowska-Szczykowska D; Laboratory of Natural Products, Department of Organic Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciolkowskiego 1K, 15-245 Bialystok, Poland.
  • Olchowik-Grabarek E; Laboratory of Molecular Biophysics, Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, K. Ciolkowskiego 1 J, 15-245 Bialystok, Poland.
  • Rárová L; Department of Experimental Biology, Faculty of Science, Palacký University, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic.
  • Sekowski S; Laboratory of Molecular Biophysics, Department of Microbiology and Biotechnology, Faculty of Biology, University of Bialystok, K. Ciolkowskiego 1 J, 15-245 Bialystok, Poland.
  • Morzycki JW; Laboratory of Natural Products, Department of Organic Chemistry, Faculty of Chemistry, University of Bialystok, K. Ciolkowskiego 1K, 15-245 Bialystok, Poland.
Molecules ; 28(1)2022 Dec 26.
Article em En | MEDLINE | ID: mdl-36615383
ABSTRACT
A chemoselective procedure for MCPBA oxidation of 26-thiodiosgenin to corresponding sulfoxides and sulfone was elaborated. An unusual equilibration of sulfoxides in solution was observed. Moreover, α-alkylation of sulfoxide and sulfone was investigated. Finally, the biological activity of obtained compounds was examined.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diosgenina Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diosgenina Idioma: En Ano de publicação: 2022 Tipo de documento: Article