Your browser doesn't support javascript.
loading
The Relationship among Bowel [18]F-FDG PET Uptake, Pathological Complete Response, and Eating Habits in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy.
Tiberio, Paola; Antunovic, Lidija; Gaudio, Mariangela; Viganò, Alessandro; Pastore, Manuela; Miggiano, Chiara; Jacobs, Flavia; Benvenuti, Chiara; Farina, Elisabetta; Chiti, Arturo; Santoro, Armando; De Sanctis, Rita.
Afiliação
  • Tiberio P; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
  • Antunovic L; Nuclear Medicine Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
  • Gaudio M; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
  • Viganò A; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy.
  • Pastore M; IRCCS Fondazione Don Carlo Gnocchi, 20148 Milan, Italy.
  • Miggiano C; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
  • Jacobs F; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
  • Benvenuti C; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy.
  • Farina E; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
  • Chiti A; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy.
  • Santoro A; Medical Oncology and Hematology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089 Milan, Italy.
  • De Sanctis R; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, 20072 Milan, Italy.
Nutrients ; 15(1)2023 Jan 01.
Article em En | MEDLINE | ID: mdl-36615868
Recently, the impact of patients' eating habits on both breast cancer (BC) management and inflammation have been proven. Here, we investigated whether inflammatory habits could correlate with baseline bowel [18]F-fluorodeoxyglucose (FDG) uptake and the latter, in turn, with pathological Complete Response (pCR) to neoadjuvant chemotherapy (NAC). We included stage I−III BC undergoing standard NAC at IRCCS Humanitas Research Hospital, Italy. Patients fulfilled a survey concerning eating/lifestyle behaviors and performed a staging [18]F-FDG positrone emission tomography/computed tomography (PET/CT). In the absence of data on the effects of individual foods, we aggregated drink and food intake for their known inflammatory properties. Data were recorded for 82 women (median age, 48). We found positive correlations between colon mean standardized uptake value (SUVmean) and pro-inflammatory drinks (alcohol and spirits; r = +0.33, p < 0.01) and foods (red and cured meats; r = +0.25, p = 0.04), and a significant negative correlation between rectum SUVmean and anti-inflammatory foods (fruits and vegetables; r = −0.23, p = 0.04). Furthermore, colon SUVmean was significantly lower in patients with pCR compared to non pCR (p = 0.02). Our study showed, for the first time, that patients' eating habits affected bowel [18]F-FDG uptake and that colon SUVmean correlated with pCR, suggesting that PET scan could be an instrument for identifying patients presenting unhealthy behaviors.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Mama Limite: Female / Humans / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article