Membrane skeleton hyperstability due to a novel alternatively spliced 4.1R can account for ellipsoidal camelid red cells with decreased deformability.

Chen, Yuqi; Miyazono, Kosuke; Otsuka, Yayoi; Kanamori, Mariko; Yamashita, Aozora; Arashiki, Nobuto; Matsumoto, Takehisa; Takada, Kensuke; Sato, Kota; Mohandas, Narla; Inaba, Mutsumi

Chen, Yuqi; Miyazono, Kosuke; Otsuka, Yayoi; Kanamori, Mariko; Yamashita, Aozora; Arashiki, Nobuto; Matsumoto, Takehisa; Takada, Kensuke; Sato, Kota; Mohandas, Narla; Inaba, Mutsumi.

Afiliação

Chen Y; Laboratory of Molecular Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Miyazono K; Laboratory of Molecular Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Otsuka Y; Laboratory of Molecular Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Kanamori M; Laboratory of Molecular Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Yamashita A; Laboratory of Molecular Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Arashiki N; Laboratory of Molecular Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan; Department of Biochemistry, School of Medicine, Tokyo Women's Medical University, Tokyo, Japan.
Matsumoto T; Drug Discovery Structural Biology Platform Unit, RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan.
Takada K; Laboratory of Molecular Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Sato K; Laboratory of Molecular Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Mohandas N; Red Cell Physiology Laboratory, New York Blood Center, New York, New York, USA.
Inaba M; Laboratory of Molecular Medicine, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan. Electronic address: inazo@vetmed.hokudai.ac.jp.

J Biol Chem ; 299(2): 102877, 2023 02.

Article em En | MEDLINE | ID: mdl-36621628

Assuntos

Processamento Alternativo; Camelídeos Americanos; Forma Celular; Proteínas do Citoesqueleto; Eritrócitos; Animais; Humanos; Actinas/metabolismo; Proteínas do Citoesqueleto/genética; Proteínas do Citoesqueleto/metabolismo; Eritrócitos/citologia; Eritrócitos/metabolismo; Membranas/metabolismo; Peptídeos/metabolismo; Ligação Proteica; Espectrina/genética; Espectrina/metabolismo; Forma Celular/genética

Palavras-chave

alternative splicing; camelid; elliptocyte; erythrocyte; hereditary elliptocytosis; membrane protein; membrane structure; plasma membrane; protein 4.1R; spectrin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Camelídeos Americanos / Processamento Alternativo / Proteínas do Citoesqueleto / Forma Celular / Eritrócitos Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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