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Genome-wide identification glutathione-S-transferase gene superfamily in Daphnia pulex and its transcriptional response to nanoplastics.
Liu, Zhiquan; Zhang, Yinan; Zheng, Yueyue; Feng, Yixuan; Zhang, Weiping; Gong, Si; Lin, Huikang; Gao, Panpan; Zhang, Hangjun.
Afiliação
  • Liu Z; School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China; State Environmental Protection Key Laboratory of Environmental Health Impact Assessment of Emerging Contaminants, Shanghai Academy of Environment Sciences, Shanghai 200233, China.
  • Zhang Y; School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China.
  • Zheng Y; School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China.
  • Feng Y; School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China.
  • Zhang W; Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China.
  • Gong S; School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China.
  • Lin H; School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China.
  • Gao P; School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China.
  • Zhang H; School of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China. Electronic address: 13819172516@163.com.
Int J Biol Macromol ; 230: 123112, 2023 Mar 01.
Article em En | MEDLINE | ID: mdl-36621743
Glutathione S-transferases (GSTs) are key multifunctional phase II detoxification enzymes involved in the regulation of growth, development, and stress responses. However, the knowledge of GSTs in the model invertebrate organism Daphnia pulex at the genomic level remains limited. In the present study, 35 GST genes were identified in D. pulex (Dp-GST), belonging to eight subfamilies, with the sigma, mu, and delta/epsilon subfamilies constituting approximately 29 %, 20 %, and 20 % of the GST superfamily, respectively. Chromosome tandem duplication of genes within the same subfamily was observed, which may be the main force driving GST expansion in D. pulex. DpGST genes showed different expression patterns in response to nanoplastic exposure for 96 h and 21 days. Some homologous GST genes in D. pulex showed similar expression patterns in response to nanoplastic exposure, likely owing to their unique motifs. For example, motif 9 is found in all delta/epsilon GST genes, whereas motifs 1, 2, 3, 5, and 7 are highly conserved in sigma GST genes. The characterization of D. pulex GSTs extending the knowledge of GST-mediated environmental contaminants, especially nanoplastics.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Daphnia / Microplásticos Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Daphnia / Microplásticos Tipo de estudo: Diagnostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article