A nonsteroidal anti-inflammatory drug, zaltoprofen, inhibits the growth of extraskeletal chondrosarcoma cells by inducing PPARÎ³, p21, p27, and p53.

Higuchi, Takashi; Takeuchi, Akihiko; Munesue, Seiichi; Yamamoto, Norio; Hayashi, Katsuhiro; Harashima, Ai; Yamamoto, Yasuhiko; Tsuchiya, Hiroyuki

Higuchi, Takashi; Takeuchi, Akihiko; Munesue, Seiichi; Yamamoto, Norio; Hayashi, Katsuhiro; Harashima, Ai; Yamamoto, Yasuhiko; Tsuchiya, Hiroyuki.

Afiliação

Higuchi T; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Takeuchi A; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Munesue S; Department of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Yamamoto N; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Hayashi K; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Harashima A; Department of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Yamamoto Y; Department of Biochemistry and Molecular Vascular Biology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Tsuchiya H; Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.

Cell Cycle ; 22(8): 939-950, 2023 04.

Article em En | MEDLINE | ID: mdl-36636023

Assuntos

Condrossarcoma; PPAR gama; Animais; Humanos; Camundongos; Anti-Inflamatórios; Proteínas de Ciclo Celular/metabolismo; Condrossarcoma/tratamento farmacológico; Condrossarcoma/metabolismo; Condrossarcoma/patologia; PPAR gama/metabolismo; Proteína Supressora de Tumor p53/genética; Inibidor de Quinase Dependente de Ciclina p27; Inibidor de Quinase Dependente de Ciclina p21

Palavras-chave

PPARÎ³; cell cycle; extraskeletal myxoid chondrosarcoma; in vivo; nonsteroidal anti-inflammatory drugs; zaltoprofen

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Condrossarcoma / PPAR gama Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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