Activation of Protease-Activated Receptor-1 Causes Chronic Pain in Lupus-Prone Mice Via Suppressing Spinal Glial Glutamate Transporter Function and Enhancing Glutamatergic Synaptic Activity.

Li, Fen; Li, Dongsheng; Liu, Jianguang; Tang, Shifan; Yan, Jie; Li, Hongwei; Wan, Zhengyun; Wang, Lian; Yan, Xisheng

Li, Fen; Li, Dongsheng; Liu, Jianguang; Tang, Shifan; Yan, Jie; Li, Hongwei; Wan, Zhengyun; Wang, Lian; Yan, Xisheng.

Afiliação

Li F; Department of Neurology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, Hubei, China.
Li D; Department of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, Hubei, China.
Liu J; Department of Neurology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, Hubei, China.
Tang S; Department of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, Hubei, China.
Yan J; Department of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, China.
Li H; Department of Internal Medicine, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Wan Z; Department of Internal Medicine, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Wang L; Department of Internal Medicine, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China.
Yan X; Department of Cardiology, Wuhan Third Hospital & Tongren Hospital of Wuhan University, Wuhan, Hubei, China. Electronic address: xishengyan2017@163.com.

J Pain ; 24(7): 1163-1180, 2023 Jul.

Article em En | MEDLINE | ID: mdl-36641029

Assuntos

Dor Crônica; Lúpus Eritematoso Sistêmico; Camundongos; Feminino; Animais; Dor Crônica/etiologia; Dor Crônica/metabolismo; Hiperalgesia/etiologia; Hiperalgesia/metabolismo; Receptor PAR-1/metabolismo; Proteínas Quinases Ativadas por AMP/metabolismo; Sistema X-AG de Transporte de Aminoácidos/metabolismo; Lúpus Eritematoso Sistêmico/metabolismo; Corno Dorsal da Medula Espinal/metabolismo; Glutamatos/metabolismo

Palavras-chave

Glutamate uptake; MRL lupus-prone; Neuroinflammation; Nociception; Protease-activated receptor-1

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor Crônica / Lúpus Eritematoso Sistêmico Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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