Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn<sup>2+</sup> coordination and substrate binding.

Du, Xueqing; Chu, Xuan; Liu, Ning; Jia, Xiaoyu; Peng, Hui; Xiao, Yazhong; Liu, Lin; Yu, Haizhu; Li, Fudong; He, Chao

Structures of the NDP-pyranose mutase belonging to glycosyltransferase family 75 reveal residues important for Mn²⁺ coordination and substrate binding.

Du, Xueqing; Chu, Xuan; Liu, Ning; Jia, Xiaoyu; Peng, Hui; Xiao, Yazhong; Liu, Lin; Yu, Haizhu; Li, Fudong; He, Chao.

Afiliação

Du X; Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui, China.
Chu X; Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui, China.
Liu N; Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui, China.
Jia X; Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui, China.
Peng H; Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui, China.
Xiao Y; Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui, China.
Liu L; Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui, China.
Yu H; Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei, China.
Li F; MOE Key Laboratory for Cellular Dynamics, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
He C; Anhui Key Laboratory of Modern Biomanufacturing and School of Life Sciences, Anhui University, Hefei, Anhui, China. Electronic address: chaohe@ahu.edu.cn.

J Biol Chem ; 299(2): 102903, 2023 02.

Article em En | MEDLINE | ID: mdl-36642179

Assuntos

Actinobacteria; Glicosiltransferases; Transferases Intramoleculares; Galactose/metabolismo; Glicosiltransferases/química; Glicosiltransferases/genética; Glicosiltransferases/metabolismo; Transferases Intramoleculares/química; Transferases Intramoleculares/genética; Transferases Intramoleculares/metabolismo; Mutagênese Sítio-Dirigida; Actinobacteria/enzimologia

Palavras-chave

GT75; NDP-furanose mutase; catalytic mechanism; crystal structure; glycosyltransferase

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicosiltransferases / Actinobacteria / Transferases Intramoleculares Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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