Human umbilical cord mesenchymal stem cell-derived exosomes carrying miR-1827 downregulate SUCNR1 to inhibit macrophage M2 polarization and prevent colorectal liver metastasis.

Chen, Jierong; Li, Ziyue; Yue, Caifeng; Ma, Jianhong; Cao, Lixue; Lin, Jiaxin; Zhu, Dandan; An, Ran; Lai, Jinxin; Guo, Yunmiao; Gu, Bing

Chen, Jierong; Li, Ziyue; Yue, Caifeng; Ma, Jianhong; Cao, Lixue; Lin, Jiaxin; Zhu, Dandan; An, Ran; Lai, Jinxin; Guo, Yunmiao; Gu, Bing.

Afiliação

Chen J; Department of Laboratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Rd, Yuexiu District, 510080, Guangzhou, Guangdong Province, P. R. China.
Li Z; Prenatal Diagnostic Center and Cord Blood Bank, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 510000, Guangzhou, P. R. China.
Yue C; Department of Laboratory Medicine, Central People's Hospital of Zhanjiang, Guangdong Medical University, Zhanjiang Central Hospital, 524045, Zhanjiang, P. R. China.
Ma J; Department of Laboratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Rd, Yuexiu District, 510080, Guangzhou, Guangdong Province, P. R. China.
Cao L; Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510080, Guangzhou, China.
Lin J; Department of Laboratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Rd, Yuexiu District, 510080, Guangzhou, Guangdong Province, P. R. China.
Zhu D; Department of Laboratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Rd, Yuexiu District, 510080, Guangzhou, Guangdong Province, P. R. China.
An R; Research Center of Medical Sciences, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 510080, Guangzhou, China.
Lai J; Department of Laboratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Rd, Yuexiu District, 510080, Guangzhou, Guangdong Province, P. R. China.
Guo Y; Zhanjiang Institute of Clinical Medicine, Central People's Hospital of Zhanjiang, Guangdong Medical University, Zhanjiang Central Hospital, 524045, Zhanjiang, Guangdong Province, P. R. China. yunmiaoguo@163.com.
Gu B; Department of Laboratory Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan 2nd Rd, Yuexiu District, 510080, Guangzhou, Guangdong Province, P. R. China. gubing@gdph.org.cn.

Apoptosis ; 28(3-4): 549-565, 2023 04.

Article em En | MEDLINE | ID: mdl-36652132

Assuntos

Neoplasias Colorretais; Exossomos; Neoplasias Hepáticas; Células-Tronco Mesenquimais; MicroRNAs; Animais; Humanos; Camundongos; Apoptose; Neoplasias Colorretais/genética; Neoplasias Colorretais/metabolismo; Exossomos/genética; Exossomos/metabolismo; Neoplasias Hepáticas/genética; Neoplasias Hepáticas/metabolismo; Macrófagos/metabolismo; Células-Tronco Mesenquimais/metabolismo; MicroRNAs/genética; MicroRNAs/metabolismo; Cordão Umbilical

Palavras-chave

Colorectal cancer; Exosomes; Human umbilical cord mesenchymal stem cells; Liver metastasis; M2 polarization; Macrophages; Succinate receptor 1; microRNA-1827

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / MicroRNAs / Exossomos / Células-Tronco Mesenquimais / Neoplasias Hepáticas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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