Phage capsid recognition triggers activation of a bacterial toxin-antitoxin defense system.

Smith, Leah M; Fineran, Peter C

Smith, Leah M; Fineran, Peter C.

Afiliação

Smith LM; Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand.
Fineran PC; Department of Microbiology and Immunology, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; Genetics Otago, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; Bioprotection Aotearoa, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand; Maurice Wilkins Centre for Molecular Biodiscovery, University of Otago, P.O. Box 56, Dunedin 9054, New Zealand. Electronic address: peter.fineran@otago.ac.nz.

Mol Cell ; 83(2): 165-166, 2023 Jan 19.

Article em En | MEDLINE | ID: mdl-36669478

ABSTRACT

ABSTRACT

Zhang et al.1 reveal a previously unknown route to toxin activation whereby bacteriophage capsid proteins bind the antitoxin domain of the CapRel fused toxin-antitoxin system, triggering translational inhibition via pyrophosporylation of tRNAs and culminating in abortive infection-mediated phage resistance.

Assuntos

Antitoxinas; Toxinas Bacterianas; Bacteriófagos; Sistemas Toxina-Antitoxina; Bacteriófagos/metabolismo; Proteínas do Capsídeo/genética; Capsídeo/metabolismo; Bactérias/metabolismo; Antitoxinas/metabolismo; Toxinas Bacterianas/genética; Toxinas Bacterianas/metabolismo; Proteínas de Bactérias/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Toxinas Bacterianas / Bacteriófagos / Antitoxinas / Sistemas Toxina-Antitoxina Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google