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Effect of a False Inertial Cue in the Velocity-Storage Circuit on Head Posture and Inertia Perception.
Choi, Jeong-Yoon; Koo, Yu Jin; Song, Jung-Mi; Kim, Hyo-Jung; Kim, Ji-Soo.
Afiliação
  • Choi JY; Dizziness Center, Clinical Neuroscience Center, and Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi 13620 South Korea saideiju@gmail.com.
  • Koo YJ; Department of Neurology, Seoul National University College of Medicine, Seoul 03080, South Korea.
  • Song JM; Dizziness Center, Clinical Neuroscience Center, and Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi 13620 South Korea.
  • Kim HJ; Dizziness Center, Clinical Neuroscience Center, and Department of Neurology, Seoul National University Bundang Hospital, Seongnam, Gyeonggi 13620 South Korea.
  • Kim JS; Research Administration Team, Seoul National University Bundang Hospital, Seongnam, Gyeonggi 13620 South Korea.
J Neurosci ; 43(9): 1530-1539, 2023 03 01.
Article em En | MEDLINE | ID: mdl-36669887
The velocity-storage circuit participates in the vestibulopostural reflex, but its role in the postural reflex requires further elucidation. The velocity-storage circuit differentiates gravitoinertial information into gravitational and inertial cues using rotational cues. This implies that a false rotational cue can cause an erroneous estimation of gravity and inertial cues. We hypothesized the velocity-storage circuit is a common gateway for all vestibular reflex pathways and tested that hypothesis by measuring the postural and perceptual responses from a false inertial cue estimated in the velocity-storage circuit. Twenty healthy human participants (40.5 ± 8.2 years old, 6 men) underwent two different sessions of earth-vertical axis rotations at 120°/s for 60 s. During each session, the participants were rotated clockwise and then counterclockwise with two different starting head positions (head-down and head-up). During the first (control) session, the participants kept a steady head position at the end of rotation. During the second (test) session, the participants changed their head position at the end of rotation, from head-down to head-up or vice versa. The head position and inertial motion perception at the end of rotation were aligned with the inertia direction anticipated by the velocity-storage model. The participants showed a significant correlation between postural and perceptual responses. The velocity-storage circuit appears to be a shared neural integrator for the vestibulopostural reflex and vestibular perception. Because the postural responses depended on the inertial direction, the postural instability in vestibular disorders may be the consequence of the vestibulopostural reflex responding to centrally estimated false vestibular cues.SIGNIFICANCE STATEMENT The velocity-storage circuit appears to participate in the vestibulopostural reflex, which stabilizes the head and body position in space. However, it is still unclear whether the velocity-storage circuit for the postural reflex is in common with that involved in eye movement and perception. We evaluated the postural and perceptual responses to a false inertial cue estimated by the velocity-storage circuit. The postural and perceptual responses were consistent with the inertia direction predicted in the velocity-storage model and were correlated closely with each other. These results show that the velocity-storage circuit is a shared neural integrator for vestibular-driven responses and suggest that the vestibulopostural response to a false vestibular cue is the pathomechanism of postural instability clinically observed in vestibular disorders.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinais (Psicologia) / Percepção de Movimento Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sinais (Psicologia) / Percepção de Movimento Tipo de estudo: Prognostic_studies Limite: Adult / Humans / Male / Middle aged Idioma: En Ano de publicação: 2023 Tipo de documento: Article