Flap Endonuclease 1 Endonucleolytically Processes RNA to Resolve R-Loops through DNA Base Excision Repair.

Laverde, Eduardo E; Polyzos, Aris A; Tsegay, Pawlos P; Shaver, Mohammad; Hutcheson, Joshua D; Balakrishnan, Lata; McMurray, Cynthia T; Liu, Yuan

Laverde, Eduardo E; Polyzos, Aris A; Tsegay, Pawlos P; Shaver, Mohammad; Hutcheson, Joshua D; Balakrishnan, Lata; McMurray, Cynthia T; Liu, Yuan.

Afiliação

Laverde EE; Biochemistry Ph.D. Program, Florida International University, Miami, FL 33199, USA.
Polyzos AA; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Tsegay PP; Biochemistry Ph.D. Program, Florida International University, Miami, FL 33199, USA.
Shaver M; Department of Biomedical Engineering, Florida International University, Miami, FL 33199, USA.
Hutcheson JD; Department of Biomedical Engineering, Florida International University, Miami, FL 33199, USA.
Balakrishnan L; Department of Biology, Indiana-Purdue University, Indianapolis, IN 46202, USA.
McMurray CT; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.
Liu Y; Biochemistry Ph.D. Program, Florida International University, Miami, FL 33199, USA.

Genes (Basel) ; 14(1)2022 12 29.

Article em En | MEDLINE | ID: mdl-36672839

Assuntos

Endonucleases Flap; Estruturas R-Loop; Humanos; DNA/genética; DNA/metabolismo; Reparo do DNA/genética; Exonucleases/genética; Endonucleases Flap/genética; Endonucleases Flap/metabolismo; Instabilidade Genômica; RNA/genética

Palavras-chave

R-loop; base excision repair (BER); flap endonuclease 1 (FEN1)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Endonucleases Flap / Estruturas R-Loop Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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