Stellate cell expression of SPARC-related modular calcium-binding protein 2 is associated with human non-alcoholic fatty liver disease severity.

Larsen, Frederik T; Hansen, Daniel; Terkelsen, Mike K; Bendixen, Sofie M; Avolio, Fabio; Wernberg, Charlotte W; Lauridsen, Mette M; Grønkjaer, Lea L; Jacobsen, Birgitte G; Klinggaard, Ellen G; Mandrup, Susanne; Di Caterino, Tina; Siersbæk, Majken S; Indira Chandran, Vineesh; Graversen, Jonas H; Krag, Aleksander; Grøntved, Lars; Ravnskjaer, Kim

Larsen, Frederik T; Hansen, Daniel; Terkelsen, Mike K; Bendixen, Sofie M; Avolio, Fabio; Wernberg, Charlotte W; Lauridsen, Mette M; Grønkjaer, Lea L; Jacobsen, Birgitte G; Klinggaard, Ellen G; Mandrup, Susanne; Di Caterino, Tina; Siersbæk, Majken S; Indira Chandran, Vineesh; Graversen, Jonas H; Krag, Aleksander; Grøntved, Lars; Ravnskjaer, Kim.

Afiliação

Larsen FT; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Hansen D; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.
Terkelsen MK; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Bendixen SM; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.
Avolio F; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Wernberg CW; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.
Lauridsen MM; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Grønkjaer LL; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.
Jacobsen BG; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
Klinggaard EG; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.
Mandrup S; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.
Di Caterino T; Department of Gastroenterology and Hepatology, University Hospital of Southern Denmark, Esbjerg, Denmark.
Siersbæk MS; Center for Liver Research (FLASH), Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark.
Indira Chandran V; Center for Functional Genomics and Tissue Plasticity (ATLAS), University of Southern Denmark, Odense, Denmark.
Graversen JH; Department of Gastroenterology and Hepatology, University Hospital of Southern Denmark, Esbjerg, Denmark.
Krag A; Department of Gastroenterology and Hepatology, University Hospital of Southern Denmark, Esbjerg, Denmark.
Grøntved L; Department of Gastroenterology and Hepatology, University Hospital of Southern Denmark, Esbjerg, Denmark.
Ravnskjaer K; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.

JHEP Rep ; 5(2): 100615, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36687468

Palavras-chave

AUROC, area under the receiver operating characteristic curve; ECM, extracellular matrix; HSC, hepatic stellate cells; LSM, liver stiffness measurement; MCP, matricellular protein; NAFL, non-alcoholic fatty liver; NAFLD; NAFLD, non-alcoholic fatty liver disease; NAS, NAFLD activity score; NASH; PCA, principal component analysis; SAF, steatosis, activity, and fibrosis; SE, sensitivity; SMOC2; SMOC2, SPARC-related modular calcium-binding protein 2; SP, specificity; SPARC, secreted protein acidic and cysteine-rich; VSMCs, vascular smooth muscle cells; WGCNA, weighted gene co-expression network analysis; aHSC, activated HSC; hepatic stellate cells; non-invasive biomarker; qHSC, quiescent HSC; smFISH, single-molecule fluorescence in situ hybridisation; transcriptomics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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